Diffraction bar-codes as high capacity optical microtags for chemical and biological applications
Birtwell, S., Galitonov, G., Whitton, A., Morgan, H. and Zheludev, N. (2006) Diffraction bar-codes as high capacity optical microtags for chemical and biological applications. In, QEP-17 at Photon06, Manchester, UK, 04 - 07 Sep 2006.
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Description/Abstract
The rapid advances in high throughput screening, combinatorial chemistry, genomic and proteomic sciences have stimulated dramatic development of new encoding strategies for bead-based assays. Several optical encoding methods are currently used in these applications, including fluorescence, Raman and magnetic tagging on microbeads. Here we describe a new method for encoding small beads which allows for non-contact reading and offer potentially millions of distinguishable tags. The tagging technique is based on fabricating a nano-structured pattern on the surface of the particle, which is only a few microns in size, read by detecting the spatial distribution of laser light diffracted by the tag. In the simplest implementation, the pattern is no more than a miniature diffraction grating, where information is coded in the pitch or spatial dimensions of the grating, read by detecting the angle of the diffracted orders. A huge increase in capacity has been achieved by using a number of superimposed gratings with different pitch and by employing two dimensional gratings. Distinguishing of tens of thousands of tags has been demonstrated on a chromium-on-glass chip library of 50 μm long tags. The technique has also been proved with biologically compatible gratings manufactured on metal nanoparticle doped SU8 photo-polymer.
| Item Type: | Conference or Workshop Item (Paper) |
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| Related URLs: | |
| Subjects: | Q Science T Technology > TK Electrical engineering. Electronics Nuclear engineering T Technology Q Science > QC Physics |
| Divisions: | University Structure - Pre August 2011 > Optoelectronics Research Centre |
| Item ID: | 57758 |
| Date Deposited: | 11 Aug 2008 |
| Last Modified: | 02 Mar 2012 12:12 |
| Contributors: | Birtwell, S. (Author) Galitonov, G. (Author) Whitton, A. (Author) Morgan, H. (Author) Zheludev, N. (Author) |
| Date: | September 2006 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/57758 |
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