Compound optimal designs for percentile estimation in dose-response models with restricted design intervals


Biedermann, Stefanie, Dette, Holger and Zhu, Wei (2007) Compound optimal designs for percentile estimation in dose-response models with restricted design intervals. Journal of Statistical Planning and Inference, 137, (12), 3838-3847. (doi:10.1016/j.jspi.2007.04.003).

This is the latest version of this item.

Download

[img] Postscript
Download (392Kb)

Description/Abstract

In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy,
particularly when human subjects are involved. We present locally optimal designs for the estimation of several percentiles simultaneously on restricted as well as unrestricted design intervals. Our results hold true for most of the commonly applied link functions with respect to the model under consideration.

Item Type: Article
ISSNs: 0378-3758 (print)
Related URLs:
Keywords: dose-response model, link function, percentile estimation, compound optimal design, a-optimality
Subjects: Q Science > QA Mathematics
R Medicine > RS Pharmacy and materia medica
H Social Sciences > HA Statistics
Divisions: University Structure - Pre August 2011 > School of Mathematics > Statistics
ePrint ID: 58642
Date Deposited: 19 Aug 2008
Last Modified: 27 Mar 2014 18:41
URI: http://eprints.soton.ac.uk/id/eprint/58642

Available Versions of this Item

Actions (login required)

View Item View Item