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Surfactant protein D in atopic dermatitis and psoriasis

Surfactant protein D in atopic dermatitis and psoriasis
Surfactant protein D in atopic dermatitis and psoriasis
The collectin surfactant protein-D (SP-D) shows antimicrobial and immuno-regulatory properties and has recently been detected in the basal layers of normal human skin. This molecule potentially plays an important role in inflammatory skin diseases and therefore SP-D content and location was examined using immunohistochemistry on skin biopsies from patients with the two major dermatologic diseases, psoriasis and atopic dermatitis. SP-D was located in the stratum basale of all biopsies with similar intense staining in both diseased and normal skin. Differences were detected in stratum spinosum where involved psoriatic skin showed intense staining through the entire region significantly different from uninvolved and normal skin. Lesional atopic skin showed moderate staining extending through the basal three-fourths of stratum spinosum. Using real time polymerase chain reaction analysis, no substantial up-regulation of SP-D mRNA was detected in lesional psoriatic skin, and a comparison of serum levels of SP-D between patients with atopic dermatitis or psoriasis and a group of age matched healthy controls did not show significant differences. In conclusion SP-D was significantly more abundant in the stratum spinosum of lesional psoriatic and atopic skin due to more cells producing the molecule rather than up-regulation of production in single cells of diseased skin. Further studies are needed to show if SP-D plays a role in the protection against skin infections or modulation of the inflammatory process in these common skin diseases.
atopic dermatitis, innate immunity, psoriasis, surfactant protein D
0906-6705
168-174
Hohwy, Thomas
30acdc5a-440f-4c42-ad92-814d4c278095
Otkjaer, Kristian
6d4b25ce-9bd9-41b3-a3e4-5eccd15e7847
Madsen, Jens
b5d8ae35-00ac-4d19-930e-d8ddec497359
Søerensen, Gritt
af086254-a312-4295-9be4-c9a07c831357
Nielsen, Ole
7656790a-07fc-44bc-bb1e-e8507cb3b30e
Vestergaard, Christian
324cdae5-5c6a-4d25-a18d-4af7f7b8bce6
Steiniche, Torben
cc26113d-1810-434a-985a-250d46bd4745
Holmskov, Uffe
8a55aecd-694c-4d61-849b-9cf32da8ba39
Lomholt, Hans
afd35975-e76f-405c-a6c6-95a9cd3cc1e9
Hohwy, Thomas
30acdc5a-440f-4c42-ad92-814d4c278095
Otkjaer, Kristian
6d4b25ce-9bd9-41b3-a3e4-5eccd15e7847
Madsen, Jens
b5d8ae35-00ac-4d19-930e-d8ddec497359
Søerensen, Gritt
af086254-a312-4295-9be4-c9a07c831357
Nielsen, Ole
7656790a-07fc-44bc-bb1e-e8507cb3b30e
Vestergaard, Christian
324cdae5-5c6a-4d25-a18d-4af7f7b8bce6
Steiniche, Torben
cc26113d-1810-434a-985a-250d46bd4745
Holmskov, Uffe
8a55aecd-694c-4d61-849b-9cf32da8ba39
Lomholt, Hans
afd35975-e76f-405c-a6c6-95a9cd3cc1e9

Hohwy, Thomas, Otkjaer, Kristian, Madsen, Jens, Søerensen, Gritt, Nielsen, Ole, Vestergaard, Christian, Steiniche, Torben, Holmskov, Uffe and Lomholt, Hans (2006) Surfactant protein D in atopic dermatitis and psoriasis. Experimental Dermatology, 15 (3), 168-174. (doi:10.1111/j.1600-0625.2006.00406.x).

Record type: Article

Abstract

The collectin surfactant protein-D (SP-D) shows antimicrobial and immuno-regulatory properties and has recently been detected in the basal layers of normal human skin. This molecule potentially plays an important role in inflammatory skin diseases and therefore SP-D content and location was examined using immunohistochemistry on skin biopsies from patients with the two major dermatologic diseases, psoriasis and atopic dermatitis. SP-D was located in the stratum basale of all biopsies with similar intense staining in both diseased and normal skin. Differences were detected in stratum spinosum where involved psoriatic skin showed intense staining through the entire region significantly different from uninvolved and normal skin. Lesional atopic skin showed moderate staining extending through the basal three-fourths of stratum spinosum. Using real time polymerase chain reaction analysis, no substantial up-regulation of SP-D mRNA was detected in lesional psoriatic skin, and a comparison of serum levels of SP-D between patients with atopic dermatitis or psoriasis and a group of age matched healthy controls did not show significant differences. In conclusion SP-D was significantly more abundant in the stratum spinosum of lesional psoriatic and atopic skin due to more cells producing the molecule rather than up-regulation of production in single cells of diseased skin. Further studies are needed to show if SP-D plays a role in the protection against skin infections or modulation of the inflammatory process in these common skin diseases.

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More information

Published date: 15 February 2006
Keywords: atopic dermatitis, innate immunity, psoriasis, surfactant protein D

Identifiers

Local EPrints ID: 59312
URI: http://eprints.soton.ac.uk/id/eprint/59312
ISSN: 0906-6705
PURE UUID: fec71396-a6ad-4208-8bbc-868c443cda86
ORCID for Jens Madsen: ORCID iD orcid.org/0000-0003-1664-7645

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Date deposited: 02 Sep 2008
Last modified: 16 Mar 2024 03:56

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Contributors

Author: Thomas Hohwy
Author: Kristian Otkjaer
Author: Jens Madsen ORCID iD
Author: Gritt Søerensen
Author: Ole Nielsen
Author: Christian Vestergaard
Author: Torben Steiniche
Author: Uffe Holmskov
Author: Hans Lomholt

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