Treatment strategies for allergy and asthma
Holgate, Stephen T. and Polosa, Riccardo. (2008) Treatment strategies for allergy and asthma. Nature Reviews Immunology, 8, (3), 218-230. (doi:10.1038/nri2262). (PMID:18274559).
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Description/Abstract
Allergic diseases have reached epidemic proportions worldwide. An understanding of the cellular and soluble mediators that are involved in allergic inflammatory responses not only helps in understanding the mechanisms of current treatments, but is also important for the identification of new targets that are amenable to both small-molecule and biological interventions. There is now considerable optimism with regards to tackling the allergy epidemic in light of improvements in systemic and mucosal allergen-specific immunotherapy, the identification of key cytokines and their receptors that drive T-helper-2-cell polarization, a clearer understanding of the pathways of leukocyte recruitment and the signalling pathways that are involved in cell activation and mediator secretion, and new approaches to vaccine development.
| Item Type: | Article |
|---|---|
| ISSNs: | 1474-1733 (print) 1474-1741 (electronic) |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology Q Science > QR Microbiology > QR180 Immunology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair |
| Item ID: | 59326 |
| Date Deposited: | 03 Sep 2008 |
| Last Modified: | 01 Jun 2011 12:18 |
| Contributors: | Holgate, Stephen T. (Author) Polosa, Riccardo. (Author) |
| Date: | March 2008 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/59326 |
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