Inflammatory cells in the airways in COPD
Inflammatory cells in the airways in COPD
Airway inflammation is central to the pathogenesis of both airway remodelling and parenchymal destruction in chronic obstructive pulmonary disease (COPD). Neutrophils, macrophages, and CD8+ T lymphocytes have been implicated in a number of studies, but a detailed profile of disease-phenotype specific inflammation has yet to emerge. The heterogeneity of the disease has hindered data interpretation while extrapolation of the results of relatively non-invasive studies to the actual pathology found in the distal lung is difficult. Moreover, prominent studies have had frequently conflicting results. Further investigations are needed to marry the different clinical phenotypes of COPD to their respective inflammatory profiles in the airways and thus improve our understanding of the pathogenesis of the disease as a whole.
smoking, chronic obstructive pulmonary disease, airway inflammation
448-454
O'Donnell, R.
ea211877-eee2-4d05-aa32-a5cca32d84e2
Breen, D.
ae7bcf3b-188e-42a3-9c8d-9d2ff31dc2d6
Wilson, S.
21c6875d-6870-441b-ae7a-603562a646b8
Djukanovic, R.
d9a45ee7-6a80-4d84-a0ed-10962660a98d
May 2006
O'Donnell, R.
ea211877-eee2-4d05-aa32-a5cca32d84e2
Breen, D.
ae7bcf3b-188e-42a3-9c8d-9d2ff31dc2d6
Wilson, S.
21c6875d-6870-441b-ae7a-603562a646b8
Djukanovic, R.
d9a45ee7-6a80-4d84-a0ed-10962660a98d
O'Donnell, R., Breen, D., Wilson, S. and Djukanovic, R.
(2006)
Inflammatory cells in the airways in COPD.
Thorax, 61 (5), .
(doi:10.1136/thx.2004.024463).
Abstract
Airway inflammation is central to the pathogenesis of both airway remodelling and parenchymal destruction in chronic obstructive pulmonary disease (COPD). Neutrophils, macrophages, and CD8+ T lymphocytes have been implicated in a number of studies, but a detailed profile of disease-phenotype specific inflammation has yet to emerge. The heterogeneity of the disease has hindered data interpretation while extrapolation of the results of relatively non-invasive studies to the actual pathology found in the distal lung is difficult. Moreover, prominent studies have had frequently conflicting results. Further investigations are needed to marry the different clinical phenotypes of COPD to their respective inflammatory profiles in the airways and thus improve our understanding of the pathogenesis of the disease as a whole.
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Published date: May 2006
Keywords:
smoking, chronic obstructive pulmonary disease, airway inflammation
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Local EPrints ID: 59384
URI: http://eprints.soton.ac.uk/id/eprint/59384
ISSN: 0040-6376
PURE UUID: ca859fc7-3ea3-422c-a8d4-1fbb0dae74a7
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Date deposited: 03 Sep 2008
Last modified: 16 Mar 2024 02:36
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Author:
R. O'Donnell
Author:
D. Breen
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