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IL13 gene polymorphism association with cord serum immunoglobulin E

IL13 gene polymorphism association with cord serum immunoglobulin E
IL13 gene polymorphism association with cord serum immunoglobulin E
Interleukin-13 (IL-13) has a pivotal role in the pathway of immunoglobulin E (IgE). Cord serum IgE has been suggested to be associated with allergy later in life, yet less affected by environmental exposures. We investigated the association of the interleukin-13 gene (IL13) polymorphisms on cord serum IgE. In the Isle of Wight birth cohort (UK, 1989–1990), cord serum IgE was measured using the ULTRA EIA® kit and was dichotomized at 0.5 kU/l (n = 1358). Five single nucleotide polymorphisms (SNPs: rs1800925 in promoter, rs2066960 in intron 1, rs1295686 in intron 3, rs20541 in exon 4 and rs1295685 in exon 4) in IL13 were genotyped by pyrosequencing method. Linkage analysis using Haploview software revealed that rs1295686, rs20541 and rs1295685 were in strong linkage disequilibrium. Logistic regression and Armitage-Cochran test were used and gene association analysis included 798 children. Confounders were maternal age; maternal smoking, household dog, and household cat during pregnancy; season of birth; sex; position of child in family; and birth weight. SNP rs1295685 was associated with raised cord serum IgE (p = 0.031). This is the first report that shows an association between IL13 polymorphism and cord serum IgE.
interleukin-13, polymorphism, immunoglobulin E
0905-6157
288-292
Sadeghnejad, Alireza
e2b0fa73-429f-4818-9f24-127f36c57752
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Arshad, S. Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Ewart, Susan
28667421-3cf7-43d7-b1c3-ca27564938f7
Sadeghnejad, Alireza
e2b0fa73-429f-4818-9f24-127f36c57752
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Arshad, S. Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Ewart, Susan
28667421-3cf7-43d7-b1c3-ca27564938f7

Sadeghnejad, Alireza, Karmaus, Wilfried, Arshad, S. Hasan and Ewart, Susan (2007) IL13 gene polymorphism association with cord serum immunoglobulin E. Pediatric Allergy and Immunology, 18 (4), 288-292. (doi:10.1111/j.1399-3038.2006.00524.x).

Record type: Article

Abstract

Interleukin-13 (IL-13) has a pivotal role in the pathway of immunoglobulin E (IgE). Cord serum IgE has been suggested to be associated with allergy later in life, yet less affected by environmental exposures. We investigated the association of the interleukin-13 gene (IL13) polymorphisms on cord serum IgE. In the Isle of Wight birth cohort (UK, 1989–1990), cord serum IgE was measured using the ULTRA EIA® kit and was dichotomized at 0.5 kU/l (n = 1358). Five single nucleotide polymorphisms (SNPs: rs1800925 in promoter, rs2066960 in intron 1, rs1295686 in intron 3, rs20541 in exon 4 and rs1295685 in exon 4) in IL13 were genotyped by pyrosequencing method. Linkage analysis using Haploview software revealed that rs1295686, rs20541 and rs1295685 were in strong linkage disequilibrium. Logistic regression and Armitage-Cochran test were used and gene association analysis included 798 children. Confounders were maternal age; maternal smoking, household dog, and household cat during pregnancy; season of birth; sex; position of child in family; and birth weight. SNP rs1295685 was associated with raised cord serum IgE (p = 0.031). This is the first report that shows an association between IL13 polymorphism and cord serum IgE.

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More information

Published date: June 2007
Keywords: interleukin-13, polymorphism, immunoglobulin E

Identifiers

Local EPrints ID: 59402
URI: http://eprints.soton.ac.uk/id/eprint/59402
ISSN: 0905-6157
PURE UUID: 9c0bf607-f285-42ea-adce-2e3ca5b0cda9

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Date deposited: 02 Sep 2008
Last modified: 15 Mar 2024 11:15

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Contributors

Author: Alireza Sadeghnejad
Author: Wilfried Karmaus
Author: S. Hasan Arshad
Author: Susan Ewart

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