Cushing's syndrome in women with polycystic ovaries and hyperandrogenism

Fegan, P. Gerry, Sandeman, Derek D., Krone, Nils, Bosman, Deborah, Wood, Peter J., Stewart, Paul M. and Hanley, Neil A. (2007) Cushing's syndrome in women with polycystic ovaries and hyperandrogenism. Nature Clinical Practice Endocrinology & Metabolism, 3, (11), 778-783. (doi:10.1038/ncpendmet0665).


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BACKGROUND: A 41-year-old woman presented to an endocrinology-gynecology clinic having been diagnosed 7 years earlier with polycystic ovarian syndrome on account of hirsutism, subfertility, greasy skin, acne and multiple ovarian cysts. Ovulation induction had led to a successful pregnancy. Subfertility recurred, however, and persisted alongside a new diagnosis of hypertension and progressive weight gain. Upon examination, the patient was hypertensive with facial plethora, rounded facies and violaceous abdominal striae. INVESTIGATIONS: Low-dose dexamethasone test, bedtime salivary and 24-h urinary free cortisol estimations, CT scan of the abdomen, and serum hormone and gonadotropin analyses. DIAGNOSIS: Cushing's syndrome due to a right adrenocortical adenoma. MANAGEMENT: The patient underwent laparoscopic right adrenalectomy, which led to resolution of all symptoms, signs and biochemical abnormalities

Item Type: Article
Digital Object Identifier (DOI): doi:10.1038/ncpendmet0665
ISSNs: 1745-8366 (print)
Related URLs:
Keywords: cortisol, cushing's syndrome, polycystic ovarian syndrome
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions : University Structure - Pre August 2011 > School of Medicine
ePrint ID: 59718
Accepted Date and Publication Date:
November 2007Published
Date Deposited: 05 Sep 2008
Last Modified: 31 Mar 2016 12:41

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