Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis


Gensch, Nicole, Borchardt, Thilo, Schneider, Andre, Riethmacher, Dieter and Braun, Thomas (2008) Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis. Development, 135, (9), 1597-1604. (doi:10.1242/dev.019331).

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Description/Abstract

The development of myogenic cells is mainly determined by expression of two myogenic factors, Myf5 and Myod1 (MyoD), which genetically compensate for each other during embryogenesis. Here, we demonstrate by conditional cell ablation in mice that Myf5 determines a distinct myogenic cell population, which also contains some Myod1-positive cells. Ablation of this lineage uncovers the presence of a second autonomous myogenic lineage, which superseded Myf5-dependent myogenic cells and expressed Myod1. By contrast, ablation of myogenin-expressing cells erased virtually all differentiated muscle cells, indicating that some aspects of the myogenic program are shared by most skeletal muscle cells. We conclude that Myf5 and Myod1 define different cell lineages with distinct contributions to muscle precursor cells and differentiated myotubes. Individual myogenic cell lineages seem to substitute for each other within the developing embryo.

Item Type: Article
ISSNs: 1011-6370 (print)
Related URLs:
Keywords: embryo, lung, germany, mice, expression,cell lineage, population, heart, research support, research, muscle, muscle cells, skeletal muscle, cell ablation, Myf5, myogenic cell lineages
Subjects: R Medicine
R Medicine > RM Therapeutics. Pharmacology
Q Science > QR Microbiology
Divisions: University Structure - Pre August 2011 > School of Health Sciences
University Structure - Pre August 2011 > School of Medicine
ePrint ID: 59743
Date Deposited: 04 Sep 2008
Last Modified: 27 Mar 2014 18:41
URI: http://eprints.soton.ac.uk/id/eprint/59743

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