Potassium leak channels and the KCNK family of two-P-domain subunits
Goldstein, Steve A.N., Bockenhauer, Detlef, O'Kelly, Ita and Zilberberg, Noam (2001) Potassium leak channels and the KCNK family of two-P-domain subunits. Nature Reviews Neuroscience, 2, (3), 175-184. (doi:10.1038/35058574).
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With a bang, a new family of potassium channels has exploded into view. Although KCNK channels were discovered only five years ago, they already outnumber other channel types. KCNK channels are easy to identify because of their unique structure--they possess two preforming domains in each subunit. The new channels function in a most remarkable fashion: they are highly regulated, potassium-selective leak channels. Although leak currents are fundamental to the function of nerves and muscles, the molecular basis for this type of conductance had been a mystery. Here we review the discovery of KCNK channels, what has been learned about them and what lies ahead. Even though two-P-domain channels are widespread and essential, they were hidden from sight in plain view--our most basic questions remain to be answered.
|Keywords:||myocardium, electrophysiology,tertiary, protein structure, family, nerve tissue, models, protein conformation,tandem pore domain,molecular, potassium channels, research support|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
University Structure - Pre August 2011 > School of Medicine
|Date Deposited:||04 Sep 2008|
|Last Modified:||27 Mar 2014 18:41|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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