Potassium leak channels and the KCNK family of two-P-domain subunits


Goldstein, Steve A.N., Bockenhauer, Detlef, O'Kelly, Ita and Zilberberg, Noam (2001) Potassium leak channels and the KCNK family of two-P-domain subunits. Nature Reviews Neuroscience, 2, (3), 175-184. (doi:10.1038/35058574).

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Original Publication URL: http://dx.doi.org/10.1038/35058574

Description/Abstract

With a bang, a new family of potassium channels has exploded into view. Although KCNK channels were discovered only five years ago, they already outnumber other channel types. KCNK channels are easy to identify because of their unique structure--they possess two preforming domains in each subunit. The new channels function in a most remarkable fashion: they are highly regulated, potassium-selective leak channels. Although leak currents are fundamental to the function of nerves and muscles, the molecular basis for this type of conductance had been a mystery. Here we review the discovery of KCNK channels, what has been learned about them and what lies ahead. Even though two-P-domain channels are widespread and essential, they were hidden from sight in plain view--our most basic questions remain to be answered.

Item Type: Article
ISSNs: 1471-003X (print)
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Keywords: myocardium, electrophysiology,tertiary, protein structure, family, nerve tissue, models, protein conformation,tandem pore domain,molecular, potassium channels, research support
Subjects: R Medicine
Divisions: University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
University Structure - Pre August 2011 > School of Medicine
ePrint ID: 59764
Date Deposited: 04 Sep 2008
Last Modified: 27 Mar 2014 18:41
URI: http://eprints.soton.ac.uk/id/eprint/59764

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