Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration
Goverdhan, S.V., Ennis, S., Hannan, S.R., Madhusudhana, K.C., Cree, A.J., Luff, A.J. and Lotery, A.J. (2008) Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration. British Journal of Ophthalmology, 92, (4), 537-540. (doi:10.1136/bjo.2007.123190) (PMID:18310311)
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Description/Abstract
Background/aims: To determine whether four expression-related cytokine polymorphisms are associated with age-related macular degeneration (AMD).
Methods: DNA from 478 cases with AMD and 555 normal controls was genotyped for the pro-inflammatory IL1beta -511C/T, IL6 -174C/G, IL8 -251A/T and anti-inflammatory IL10 -1082G/A cytokine polymorphisms using the 5' nuclease TaqMan(R) assay for allelic discrimination. Associations with AMD were analysed using allelic frequencies.
Results: The -251A allele of the IL8 promoter gene polymorphism was more prevalent in AMD patients than controls (p = 0.037, OR = 1.21, 95% CI = 1.01 to 1.44). Adjusting for age, sex, body mass index (BMI), current smoking and past smoking status did not alter the AMD association significantly (corrected p value = 0.043, OR = 1.23, 95% CI = 1.0 to 1.50).
Conclusion: The pro-inflammatory homozygous IL8 -251AA genotype is an important risk factor for AMD. This may have implications for future therapy with biological agents that could target this cytokine.
| Item Type: | Article |
|---|---|
| ISSN: | 0007-1161 (print) |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RE Ophthalmology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences |
| ePrint ID: | 59778 |
| URI: | http://eprints.soton.ac.uk/id/eprint/59778 |
| Deposited On: | 29 Oct 2008 |
| Last Modified: | 01 Nov 2011 03:23 |
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