The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women's Heart and Health cohort study


Lawlor, Debbie A., Gaunt, Tom R., Hinks, Lesley J., Smith, George Davey, Timpson, Nick, Day, Ian N.M. and Ebrahim, Shah (2006) The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women's Heart and Health cohort study. Paediatric and Perinatal Epidemiology, 20, (3), 244-250. (doi:10.1111/j.1365-3016.2006.00716.x).

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Description/Abstract

It has been hypothesised that paraoxonase genes would be related to adverse pregnancy outcomes, via a maternal or fetal effect on placental hypoperfusion and thrombosis. To date only two studies have assessed this possibility. In this study we assessed the associations of the PON1 Q192R polymorphism with self-report of having pregnancy-induced hypertension, gestational hyperglycaemia and a preterm offspring birth. The associations were assessed in 3266 white women who were randomly selected from 23 British towns. There was no association between PON1 Q192R and either self-report of pregnancy-induced hypertension or gestational hyperglycaemia but the prevalence of reporting having a preterm birth increased with each R allele: per allele odds ratio 1.20 [95% confidence interval (CI) 1.03, 1.41]. When our results were pooled with the one previous study of the association of this polymorphism with preterm birth, the pooled per allele odds ratio was 1.19 [95% CI 1.02, 1.39]. Our findings provide some further evidence to suggest that PON1 Q192R is associated with preterm birth; they invite further investigation of both maternal and fetal genotype for PON1 Q192R in relation to preterm birth.

Item Type: Article
ISSNs: 0269-5022 (print)
Keywords: pregnancy complications, pregnancy outcome, heart, physiology, genetics, infant, cohort, fetal, health, pregnancy, infant, polymorphism, epidemiology, hypertension, complications
Subjects: R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Q Science > QH Natural history > QH426 Genetics
R Medicine > RG Gynecology and obstetrics
Divisions: University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences
University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
University Structure - Pre August 2011 > School of Medicine > Human Genetics
ePrint ID: 59970
Date Deposited: 05 Sep 2008
Last Modified: 27 Mar 2014 18:42
URI: http://eprints.soton.ac.uk/id/eprint/59970

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