X chromosome loss and ageing


Russell, L.M., Strike, P., Browne, C.E. and Jacobs, P.A. (2007) X chromosome loss and ageing. Cytogenetic and Genome Research, 116, (3), 181-185. (doi:10.1159/000098184).

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Original Publication URL: http://dx.doi.org/10.1159/000098184

Description/Abstract

The detection of a low level 45,X cell line during routine cytogenetic analysis in an adult female can be difficult to interpret. In the absence of recent information regarding loss of the X chromosome and ageing, we undertook a prospective study. A total of 19,650 cells from 655 females aged from birth to 80 years were screened cytogenetically. The frequency of X chromosome loss ranged from 0.07% at age 65 years of age and showed a highly significant quadratic relationship between X chromosome loss and ageing (P < or = 0.00001). We have produced a graphic representation that provides a minimum baseline age-related rate of X chromosome loss. This should assist diagnostic cytogenetics laboratories to determine the significance of 45,X cell lines detected in women of all ages. We also compared the frequency of 45,X cells in women referred with at least one spontaneous abortion with those referred for other reasons and found no significant difference. Thus, in our population, an excess of 45,X cells is not associated with pregnancy loss.

Item Type: Article
ISSNs: 1424-8581 (print)
Related URLs:
Keywords: newborn, infant, chromosomes, child, prospective studies,preschool, aging,x, adult, genetics, cytogenetics, aged, middle aged,human,abortion, infant, age distribution, cell line, humans
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Q Science > QR Microbiology
Divisions: University Structure - Pre August 2011 > School of Medicine
University Structure - Pre August 2011 > School of Medicine > Human Genetics
ePrint ID: 60197
Date Deposited: 08 Sep 2008
Last Modified: 27 Mar 2014 18:42
URI: http://eprints.soton.ac.uk/id/eprint/60197

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