Clinical implications of apoptosis in ischemic myocardium


Scarabelli, Tiziano M., Knight, Richard, Stephanou, Anastasis, Townsend, Paul, Chen-Scarabelli, Carol, Lawrence, Kevin, Gottlieb, Roberta, Latchman, David and Narula, Jagat (2006) Clinical implications of apoptosis in ischemic myocardium. Current Problems in Cardiology, 31, (3), 181-264. (doi:10.1016/j.cpcardiol.2005.11.002).

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Description/Abstract

Apoptosis, a genetically programmed form of cell death, contributes to myocyte cell loss in a variety of cardiac pathologies, including cardiac failure and those related to ischemia/reperfusion injury. The apoptotic program is complex, involving both pro- and anti-apoptotic proteins, and apoptosis occurs when the equilibrium between these opposing factors is perturbed. Some of these factors are intrinsic to the apoptotic pathway, such as the pro- and anti-apoptotic members of the Bcl2 family. Other, extrinsic, cellular factors can also modify the outcome of the response to an apoptotic stimulus. In this review, we have focused on some of these extrinsic factors, such as STAT-1 as a pro-apoptotic agent and the urocortins and Bag-1 as anti-apoptotic factors, since these may be potential therapeutic targets. In addition, we discuss the profound cytoprotective effects of the antibiotic, minocycline.

Item Type: Article
ISSNs: 0146-2806 (print)
Related URLs:
Keywords: myocardial reperfusion injury, injuries, urocortins, review, apoptosis regulatory proteins, stat transcription factors, minocycline, protein, animals, myocardial ischemia, autophagy
Subjects: R Medicine > RB Pathology
R Medicine > RD Surgery
R Medicine
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
University Structure - Pre August 2011 > School of Health Sciences
University Structure - Pre August 2011 > School of Medicine
ePrint ID: 60210
Date Deposited: 08 Sep 2008
Last Modified: 27 Mar 2014 18:42
URI: http://eprints.soton.ac.uk/id/eprint/60210

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