Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10


Sonnenberg-Riethmacher, Eva, Miehe, Michaela, Stolt, Claus C., Goerich, Derk E., Wegner, Michael and Riethmacher, Dieter (2001) Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10. Mechanisms of Development, 109, (2), 253-265. (doi:10.1016/S0925-4773(01)00547-0).

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Description/Abstract

The HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.

Item Type: Article
ISSNs: 0925-4773 (print)
Related URLs:
Keywords: cell differentiation, lac operon, in situ hybridization, ganglia, germany, differentiation, cell lineage, physiology,spinal, homozygote,analysis, chemistry, neurons, transcription factors
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Q Science > QR Microbiology
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
University Structure - Pre August 2011 > School of Medicine
University Structure - Pre August 2011 > School of Medicine > Human Genetics
ePrint ID: 60250
Date Deposited: 08 Sep 2008
Last Modified: 27 Mar 2014 18:42
URI: http://eprints.soton.ac.uk/id/eprint/60250

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