Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10


Stolt, C. Claus, Rehberg, Stephan, Ader, Marius, Lommes, Petra, Riethmacher, Dieter, Schachner, Melitta, Bartsch, Udo and Wegner, Michael (2002) Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes & development, 16, (2), 165-170. (doi:10.1101/gad.215802).

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Original Publication URL: http://dx.doi.org/10.1101/gad.215802

Description/Abstract

Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.

Item Type: Article
ISSNs: 0890-9369 (print)
Related URLs:
Keywords: sox, glial cells, HMG, PLP, MBP, neuregulin
Subjects: R Medicine > R Medicine (General)
R Medicine
Q Science > QR Microbiology
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
University Structure - Pre August 2011 > School of Medicine
University Structure - Pre August 2011 > School of Medicine > Human Genetics
ePrint ID: 60264
Date Deposited: 08 Sep 2008
Last Modified: 27 Mar 2014 18:42
URI: http://eprints.soton.ac.uk/id/eprint/60264

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