Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
Stolt, C. Claus, Rehberg, Stephan, Ader, Marius, Lommes, Petra, Riethmacher, Dieter, Schachner, Melitta, Bartsch, Udo and Wegner, Michael (2002) Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes & development, 16, (2), 165-170. (doi:10.1101/gad.215802).
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Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.
|Digital Object Identifier (DOI):||doi:10.1101/gad.215802|
|Keywords:||sox, glial cells, HMG, PLP, MBP, neuregulin|
|Subjects:||R Medicine > R Medicine (General)
Q Science > QR Microbiology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
University Structure - Pre August 2011 > School of Medicine
University Structure - Pre August 2011 > School of Medicine > Human Genetics
|Date Deposited:||08 Sep 2008|
|Last Modified:||06 Aug 2015 02:48|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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