Linkage disequilibrium maps and location databases
Tapper, William (2008) Linkage disequilibrium maps and location databases. In, Collins, Andrew R. (eds.) Linkage Disequilibrium and Association Mapping: Analysis and Applications. Totowa, USA, Humana, 23-45. (Methods in Molecular Biology 376). (doi:10.1007/978-1-59745-389-9_3).
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Effective application of association mapping for complex traits requires characterization of linkage disequilibrium (LD) patterns that reflect the dominant process of recombination and its duration in addition to the more subtle influences of mutation, selection, and genetic drift. Maps expressed in linkage disequilibrium units (LDUs) reflect the influences of these factors with the use of a modified version of Malecot’s isolation-by-distance model. As a result, LDU maps are analogous to linkage maps in so far as their provision of an additive metric that is related to recombination and facilitates association-mapping studies. However, unlike linkage maps, LDUs also reflect the partly cumulative effects of multiple historical bottlenecks that account for substantial variations in LD patterns between populations. This chapter provides an overview of the data requirements and methodology used to construct LDU maps, their applications outside association mapping, and their integration into location databases.
|Item Type:||Book Section|
|Digital Object Identifier (DOI):||doi:10.1007/978-1-59745-389-9_3|
|Additional Information:||ISSN 1064-3745|
|Keywords:||linkage disequilibrium unit, malecot model, recombination, hot spot, snp selectiongene mapping, methods, genomics, statistical methods|
|Subjects:||Z Bibliography. Library Science. Information Resources > ZA Information resources > ZA4450 Databases
Q Science > QH Natural history > QH426 Genetics
Q Science > QA Mathematics > QA76 Computer software
|Divisions:||University Structure - Pre August 2011 > School of Medicine
|Date Deposited:||28 Oct 2008|
|Last Modified:||31 Mar 2016 12:42|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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