Linkage disequilibrium maps and location databases


Tapper, William (2008) Linkage disequilibrium maps and location databases. In, Collins, Andrew R. (ed.) Linkage Disequilibrium and Association Mapping: Analysis and Applications. Totowa, USA, Humana, 23-45. (Methods in Molecular Biology 376). (doi:10.1007/978-1-59745-389-9_3).

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Description/Abstract

Effective application of association mapping for complex traits requires characterization of linkage disequilibrium (LD) patterns that reflect the dominant process of recombination and its duration in addition to the more subtle influences of mutation, selection, and genetic drift. Maps expressed in linkage disequilibrium units (LDUs) reflect the influences of these factors with the use of a modified version of Malecot’s isolation-by-distance model. As a result, LDU maps are analogous to linkage maps in so far as their provision of an additive metric that is related to recombination and facilitates association-mapping studies. However, unlike linkage maps, LDUs also reflect the partly cumulative effects of multiple historical bottlenecks that account for substantial variations in LD patterns between populations. This chapter provides an overview of the data requirements and methodology used to construct LDU maps, their applications outside association mapping, and their integration into location databases.

Item Type: Book Section
Additional Information: ISSN 1064-3745
ISBNs: 9781588296696 (hardback)
Related URLs:
Keywords: linkage disequilibrium unit, malecot model, recombination, hot spot, snp selectiongene mapping, methods, genomics, statistical methods
Subjects: Z Bibliography. Library Science. Information Resources > ZA Information resources > ZA4450 Databases
Q Science > QH Natural history > QH426 Genetics
Q Science > QA Mathematics > QA76 Computer software
Divisions: University Structure - Pre August 2011 > School of Medicine
ePrint ID: 60285
Date Deposited: 28 Oct 2008
Last Modified: 27 Mar 2014 18:42
URI: http://eprints.soton.ac.uk/id/eprint/60285

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