Genetic association with rheumatoid arthritis - Genetic Analysis Workshop 15: summary of contributions from Group 2
Wilcox, Marsha A., Li, Zhong and Tapper, Will (2007) Genetic association with rheumatoid arthritis - Genetic Analysis Workshop 15: summary of contributions from Group 2. Genetic Epidemiology, 31, (S1), S12-S21. (doi:10.1002/gepi.20276).
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The papers in presentation group 2 of Genetic Analysis Workshop 15 (GAW15) conducted association analyses of rheumatoid arthritis data. The analyses were carried out primarily in the data provided by the North American Rheumatoid Arthritis Consortium (NARAC). One group conducted analyses in the data provided by the Canadian Rheumatoid Arthritis Genetics Study (CRAGS). Analysis strategies included genome-wide scans, the examination of candidate genes, and investigations of a region of interest on chromosome 18q21. Most authors employed relatively new methods, proposed extensions of existing methods, or introduced completely novel methods for aspects of association analysis. There were several common observations; a group of papers using a variety of methods found stronger association, on chromosomes 6 and 18 and in candidate gene PTPN22 among women with early onset. Generally, models that considered haplotypes or multiple markers showed stronger evidence for association than did single marker analyses.
|Additional Information:||Supplement: Genetic Analysis Workshop 15: Summaries of the Design and Analysis of Genomic Data.|
|Subjects:||R Medicine > RC Internal medicine|
|Divisions:||University Structure - Pre August 2011 > School of Medicine
|Date Deposited:||19 Nov 2008|
|Last Modified:||27 Mar 2014 18:42|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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