A 2-year-old with atypical CML with a t(5;12)(q33;p13) treated successfully with imatinib mesylate
Wittman, Brenda, Horan, John, Baxter, Joanna, Goldberg, John, Felgar, Raymond, Baylor, Erin, Cromwell, Bean, Cross, Nicholas and Bennett, John M. (2004) A 2-year-old with atypical CML with a t(5;12)(q33;p13) treated successfully with imatinib mesylate. Leukemia Research, 28, (Supplement 1), 65-69. (doi:10.1016/j.leukres.2003.10.011).
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Description/Abstract
Atypical chronic myelogenous leukemia (aCML) is a myelodysplastic/myeloproliferative disorder that usually occurs in older adults. Here we report a pediatric patient with aCML and a t(5;12)(q33;p13) with a corresponding fusion gene ETV6-PDGFRB. Because the PDGFRB tyrosine kinase is one of the known targets of tyrosine kinase inhibitors, this patient achieved cytogenetic and molecular remission with treatment with imatinib mesylate (formerly STI571; now Gleevec in the United States and Glivec in Europe). This case illustrates one of many myelodysplastic/myeloproliferative disorders that can be treated with this particular tyrosine kinase inhibitor.
| Item Type: | Article |
|---|---|
| ISSNs: | 0145-2126 (print) |
| Related URLs: | |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services |
| Divisions: | University Structure - Pre August 2011 > School of Medicine |
| Item ID: | 60436 |
| Date Deposited: | 19 Nov 2008 |
| Last Modified: | 01 Jun 2011 05:02 |
| Contributors: | Wittman, Brenda (Author) Horan, John (Author) Baxter, Joanna (Author) Goldberg, John (Author) Felgar, Raymond (Author) Baylor, Erin (Author) Cromwell, Bean (Author) Cross, Nicholas (Author) Bennett, John M. (Author) |
| Date: | May 2004 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/60436 |
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