Antenatal carbimazole and choanal atresia: a new embryopathy
Wolf, D., Foulds, N. and Daya, H. (2006) Antenatal carbimazole and choanal atresia: a new embryopathy. Archives of Otolaryngology - Head & Neck Surgery, 132, (9), 1009-1011.
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Description/Abstract
Carbimazole embryopathy is a recently recognized and defined phenotype. Choanal atresia; gastrointestinal anomalies, particularly esophageal atresia; athelia or hypothelia; developmental delay; hearing loss; aplasia cutis; and dysmorphic facial features all can occur after exposure to the antithyroid drugs carbimazole or methimazole during gestation. Although full expression of this phenotype appears to be an uncommon sequelae of antenatal carbimazole exposure, infants with less overt manifestations may remain with the condition undiagnosed. It is clearly important when an infant with choanal atresia is assessed to take an adequate drug history and consider this embryopathy as a potential causative factor
| Item Type: | Article |
|---|---|
| ISSNs: | 0886-4470 (print) |
| Related URLs: | |
| Keywords: | infant, abnormalities, expression, choanal atresia, humans, multiple, adverse effects, exposure, agents, infant, pregnancy complications, london, pregnancy, carbimazole, drug therapy, graves disease,newborn, report, hearing loss, england, phenotype, genetics, therapeutic use, female, antithyroid agents, chemically induced, history |
| Subjects: | R Medicine |
| Divisions: | University Structure - Pre August 2011 > School of Medicine |
| Item ID: | 60438 |
| Date Deposited: | 04 Sep 2008 |
| Last Modified: | 01 Jun 2011 09:41 |
| Contributors: | Wolf, D. (Author) Foulds, N. (Author) Daya, H. (Author) |
| Date: | 2006 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/60438 |
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