Linkage disequilibrium as a tool for detecting signatures of natural selection
Ennis, Sarah (2008) Linkage disequilibrium as a tool for detecting signatures of natural selection. In, Collins, Andrew R. (ed.) Linkage Disequilibrium and Association Mapping: Analysis and Applications. Totowa, USA, Humana, 59-70. (Methods in Molecular Biology, 376). (doi:10.1007/978-1-59745-389-9_5)
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Official URL: http://dx.doi.org/10.1007/978-1-59745-389-9_5
Description/Abstract
Natural selection has been theoretically and empirically proven to alter patterns of linkage disequilibrium (LD). Reciprocally, recombination, the driving force behind LD, modifies the signature of natural selection by reintroducing variation in a punctuate manner across the genome. To date, efforts to identify genes that have been subjected to historical selective pressure by examining polymorphic variation and allelic association have frequently fallen short of unambiguously distinguishing selection from other biological mechanisms. Contemporary genetic maps that describe LD in fine detail represent a much needed tool that can be exploited by researchers aiming to tease apart these opposing signals.
| Item Type: | Book Section |
|---|---|
| ISBN: | 9781588296696 (hardback) |
| Uncontrolled Keywords: | gene mapping, genomics statistical methods |
| Related URLs: | http://www.ncbi.nlm.nih.gov/pu...d/17984538 http://dx.doi.org/10.1007/978-...45-389-9_5 |
| Subjects: | Q Science > QH Natural history > QH426 Genetics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Human Genetics |
| ePrint ID: | 60574 |
| URI: | http://eprints.soton.ac.uk/id/eprint/60574 |
| Deposited On: | 11 Sep 2008 |
| Last Modified: | 02 Mar 2012 12:51 |
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