The University of Southampton
University of Southampton Institutional Repository

Polymorphism of the IGF2 gene, birth weight and grip strength in adult men

Polymorphism of the IGF2 gene, birth weight and grip strength in adult men
Polymorphism of the IGF2 gene, birth weight and grip strength in adult men
Background: grip strength is a simple measure of skeletal muscle function but a powerful predictor of disability, morbidity and mortality. Recent evidence has shown that prenatal and infant growth influence grip strength in later life; this may reflect genetic influences on muscle size and function, although strong candidate genes have not been identified. IGF II has proliferative effects in adult muscle and is one of the major determinants of fetal growth; polymorphism in the IGF2 gene could therefore link early growth to adult grip strength.
Objectives: to determine whether polymorphism of the IGF2 gene influences adult grip strength and mediates the association between size at birth and grip strength in later life.
Methods: polymorphism of the ApaI marker in the IGF2 gene was determined for 693 Hertfordshire men and women born between 1920 and 1930 who had taken part in a study linking early growth to ageing. Grip strength was measured using isometric dynamometry. Genotyping assay development was undertaken in Southampton Genetic Epidemiology Laboratories (http://www.sgel.humgen.soton.ac.uk).
Results: in univariate analyses, IGF2 genotype and birth weight were both significant predictors of adult grip strength in the men after adjustment for age and current height. Significant associations were not seen in the women. When IGF2 genotype and birth weight in men were studied simultaneously, both contributed significantly to grip strength after adjustment for age and adult height.
Conclusions: these results show that polymorphism of the IGF2 gene and birth weight have independent effects on adult grip strength in men and suggest that IGF2 polymorphism does not explain the association between size at birth and grip in later life. This study provides preliminary evidence for independent genetic and early environmental programming of adult muscle strength.
grip strength, IGF2 gene, growth, birth weight
0002-0729
468-470
Sayer, A.A.
22ab6f4d-9d83-4272-9f56-1c2787598509
Syddall, H.
a0181a93-8fc3-4998-a996-7963f0128328
O'Dell, S.D.
7879476b-b069-4cd8-9917-33debec87860
Chen, X.H.
fe7ddffb-99db-4473-8d70-c9ecc07f2b16
Briggs, P.J.
6c060703-0b71-4128-a5d3-cc46a5e35dbf
Briggs, R.
a6b65ef0-e90c-4c07-bf5b-b70130c128b3
Day, I.N.
e9cacaf7-f4c8-4ef0-82fa-b459ad683d50
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sayer, A.A.
22ab6f4d-9d83-4272-9f56-1c2787598509
Syddall, H.
a0181a93-8fc3-4998-a996-7963f0128328
O'Dell, S.D.
7879476b-b069-4cd8-9917-33debec87860
Chen, X.H.
fe7ddffb-99db-4473-8d70-c9ecc07f2b16
Briggs, P.J.
6c060703-0b71-4128-a5d3-cc46a5e35dbf
Briggs, R.
a6b65ef0-e90c-4c07-bf5b-b70130c128b3
Day, I.N.
e9cacaf7-f4c8-4ef0-82fa-b459ad683d50
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Sayer, A.A., Syddall, H., O'Dell, S.D., Chen, X.H., Briggs, P.J., Briggs, R., Day, I.N. and Cooper, C. (2002) Polymorphism of the IGF2 gene, birth weight and grip strength in adult men. Age and Ageing, 31 (6), 468-470.

Record type: Article

Abstract

Background: grip strength is a simple measure of skeletal muscle function but a powerful predictor of disability, morbidity and mortality. Recent evidence has shown that prenatal and infant growth influence grip strength in later life; this may reflect genetic influences on muscle size and function, although strong candidate genes have not been identified. IGF II has proliferative effects in adult muscle and is one of the major determinants of fetal growth; polymorphism in the IGF2 gene could therefore link early growth to adult grip strength.
Objectives: to determine whether polymorphism of the IGF2 gene influences adult grip strength and mediates the association between size at birth and grip strength in later life.
Methods: polymorphism of the ApaI marker in the IGF2 gene was determined for 693 Hertfordshire men and women born between 1920 and 1930 who had taken part in a study linking early growth to ageing. Grip strength was measured using isometric dynamometry. Genotyping assay development was undertaken in Southampton Genetic Epidemiology Laboratories (http://www.sgel.humgen.soton.ac.uk).
Results: in univariate analyses, IGF2 genotype and birth weight were both significant predictors of adult grip strength in the men after adjustment for age and current height. Significant associations were not seen in the women. When IGF2 genotype and birth weight in men were studied simultaneously, both contributed significantly to grip strength after adjustment for age and adult height.
Conclusions: these results show that polymorphism of the IGF2 gene and birth weight have independent effects on adult grip strength in men and suggest that IGF2 polymorphism does not explain the association between size at birth and grip in later life. This study provides preliminary evidence for independent genetic and early environmental programming of adult muscle strength.

This record has no associated files available for download.

More information

Published date: 2002
Keywords: grip strength, IGF2 gene, growth, birth weight

Identifiers

Local EPrints ID: 60835
URI: http://eprints.soton.ac.uk/id/eprint/60835
ISSN: 0002-0729
PURE UUID: ce996ad4-0536-427c-9212-72a1589a64f0
ORCID for H. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 03 Sep 2008
Last modified: 18 Mar 2024 02:48

Export record

Contributors

Author: A.A. Sayer
Author: H. Syddall ORCID iD
Author: S.D. O'Dell
Author: X.H. Chen
Author: P.J. Briggs
Author: R. Briggs
Author: I.N. Day
Author: C. Cooper ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×