Maternal and social origins of hypertension
Barker, D.J., Osmond, C., Forsen, T.J., Kajantie, E. and Eriksson, J.G. (2007) Maternal and social origins of hypertension. Hypertension, 50, (3), 565-571. (doi:10.1161/HYPERTENSIONAHA.107.091512).
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We previously reported that in 2003 people from the Helsinki birth cohort whose blood pressures were measured, 2 different paths of growth preceded the development of hypertension. People already diagnosed with hypertension were small at birth but of average body size at age 11 years. People newly diagnosed with hypertension grew slowly in utero and through childhood. We have now examined how the mother's body size, placental size, and living conditions after birth, 3 influences that affect growth, affect hypertension. Diagnosed hypertension was associated with low placental weight and poor living conditions after birth. The odds ratios were 1.6 (95% CI, 1.1 to 2.3) in people with placental weights /=19 cm. We conclude that one path of growth that leads to hypertension is initiated by fetal undernutrition, which may make a baby vulnerable to postnatal stress, whereas the other originates in a functional incapacity in the mother's metabolism, possibly protein metabolism, which she acquired through undernutrition during her infancy.
|Digital Object Identifier (DOI):||doi:10.1161/HYPERTENSIONAHA.107.091512|
|Keywords:||hypertension, cohort, stress,birth, blood, maternal, body size, mothers, origins, heart, in-utero, health, weight, fathers, research, protein, cardiovascular disease, metabolism, size, childhood, odds ratio, undernutrition, growth, development, fetal, malnutrition, blood pressure|
Q Science > QP Physiology
|Divisions :||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Accepted Date and Publication Date:||
|Date Deposited:||11 Sep 2008|
|Last Modified:||31 Mar 2016 12:43|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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