Human growth and cardiovascular disease

Barker, D. (2008) Human growth and cardiovascular disease. In, Barker, D.J.P., Bergmann, R.L. and Ogra, P.L. (eds.) The Window of Opportunity: Pre-Pregnancy to 24 Months of Age. 61st Nestlé Nutrition Workshop, Pediatric Program: Environmental Factors and the Development of Human Health Basel, Switzerland, Karger, 21-38. (Nestlé Nutrition Workshop Series: Pediatric Program, 61). (doi:10.1159/000113163).


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Low birthweight is now known to be associated with increased rates of coronary heart disease (CHD) and the related disorders, stroke, hypertension and type 2 diabetes. Associations between low birthweight and later disease have been extensively replicated in studies in different countries. They extend across the normal range of birthweight and depend on lower birthweights in relation to the duration of gestation rather than the effects of premature birth. The associations are thought to be consequences of developmental plasticity, the phenomenon by which one genotype can give rise to a range of different physiological or morphological states in response to different environmental conditions during development. Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth. CHD and the disorders related to it arise through a series of interactions between environmental influences and the pathways of growth and development that precede them.

Item Type: Book Section
Digital Object Identifier (DOI): doi:10.1159/000113163
Additional Information: ISSN 1661-6677
Related URLs:
Keywords: birth, preschool, weight, maternal nutrition physiology, growth, cardiovascular disease, premature, prenatal care, child, hypertension, stroke, infant, health, humans, cardiovascular-disease, physiology, prenatal nutrition physiology, cardiovascular diseases, heart, developmental plasticity, male, diabetes, cardiovascular, pregnancy, environmental, infant, review, premature birth, etiology, infant,newborn, genotype, consequences, child, childhood, child nutrition physiology, coronary heart disease, epidemiology, child development, growth & development, female, human, disease, infant, development, low birth weight, weight gain
Subjects: R Medicine > RB Pathology
R Medicine > RG Gynecology and obstetrics
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 60890
Accepted Date and Publication Date:
Date Deposited: 26 Sep 2008
Last Modified: 31 Mar 2016 12:43

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