Mid-facial anthropometry in second-trimester fetuses with trisomy 21: a three-dimensional ultrasound study

Bergann, Anna, Bamberg, Christian, Eder, Katja, Proquitte, Hans, Hartung, John P., Bollmann, Rainer and Kalache, Karim D. (2006) Mid-facial anthropometry in second-trimester fetuses with trisomy 21: a three-dimensional ultrasound study. Prenatal Diagnosis, 26, (2), 158-162. (doi:10.1002/pd.1362).


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Original Publication URL: http://dx.doi.org/10.1002/pd.1362


Objectives: The aim of this study was to evaluate whether fetuses with trisomy 21 and detectable nasal bones have a distinct facial anthropometry that can be objectively defined using three-dimensional (3D) ultrasonography.

Methods: A prospective cross-sectional study of 40 fetuses in the second trimester, 17 with trisomy 21 and 23 controls, was performed. The 3D volume datasets of each case were evaluated for documentation of the nasal bones using the multiplanar and the maximum mode. The nasal bone length and the angle formed by the two maxillary bones at the level of the frontal process were then measured.

Results: The nasal bones were absent in 7 (41%) of the 17 fetuses with Down syndrome. All of the 23 normal fetuses had detectable nasal bones. The difference between nasal bone length in trisomy 21 fetuses and controls did not reach statistical significance (p = 0.087). The mean maxillary angle in trisomy 21 fetuses with nasal bones was significantly wider compared to controls (p = 0.029).

Conclusions: The nasal bones are present in the majority of fetuses with trisomy 21 in the second trimester. This group of fetuses has a characteristic mid-facial anthropometry (wider maxillary angle) that can be assessed by means of 3D ultrasonography.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/pd.1362
Additional Information:
ISSNs: 0197-3851 (print)
Related URLs:
Keywords: nasal bones, maxilla, trisomy 22, three-dimensional, ultrasonography, prenatal diagnosis
Subjects: R Medicine > RG Gynecology and obstetrics
Q Science > QH Natural history > QH426 Genetics
Divisions : University Structure - Pre August 2011 > School of Medicine
ePrint ID: 60912
Accepted Date and Publication Date:
6 February 2006Published
Date Deposited: 23 Sep 2008
Last Modified: 31 Mar 2016 12:43
URI: http://eprints.soton.ac.uk/id/eprint/60912

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