Human fibroblast and human bone marrow cell response to lithographically nanopatterned adhesive domains on protein rejecting substrates


Berry, C.C., Curtis, A.S.G., Oreffo, R.O.C., Agheli, H.D.S. and Sutherland, D.S. (2007) Human fibroblast and human bone marrow cell response to lithographically nanopatterned adhesive domains on protein rejecting substrates. IEEE Transactions on Nanobioscience, 6, (3), 201-209. (doi:10.1109/TNB.2007.903457).

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Original Publication URL: http://dx.doi.org/10.1109/TNB.2007.903457

Description/Abstract

The separate influence of topographical and chemical cues on cell attachment and spreading are well documented; however, that of duel-cue substrates is less so. In this study graft copolymers that sterically stabilize biological surfaces were employed alongside nanotopographical features fabricated by colloidal lithography. This resulted in the production of a range of substrates whereby the effect of chemistry and or topography on both on human fibroblast and bone marrow cell adhesion and spreading could be observed. The current studies indicate an enhancement of cell response as a consequence of modifications in material topography, whereas the current selected chemical cues inhibited cell function. Critically, in combination, topography modulated the effects of chemical environment.

Item Type: Article
ISSNs: 1536-1241 (print)
Related URLs:
Keywords: cytology, cell survival,cultured, research, humans, human, cues, fibroblasts, methods, proteins, surface properties, tissue engineering, environment, cell adhesion, substrate specificity, cell proliferation, cells, bone, ultrastructure, nanostructures,biocompatible materials, bone marrow, cell culture techniques, metabolism, function, materials testing, bone marrow cells, protein, physiology, chemistry
Subjects: R Medicine > RB Pathology
Q Science > QP Physiology
Divisions: University Structure - Pre August 2011 > School of Medicine
ePrint ID: 60914
Date Deposited: 23 Sep 2008
Last Modified: 28 Mar 2014 15:20
Research Funder: BBSRC
Projects:
HT chemical manipulation of foetal and adult stem cells - selection transfection and scaffold identification
Funded by: BBSRC (BB/D013682/1)
Led by: Richard Oreffo
1 November 2006 to 31 October 2009
URI: http://eprints.soton.ac.uk/id/eprint/60914

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