Metabolism of alpha-linolenic acid in humans
Burdge, G.C. (2006) Metabolism of alpha-linolenic acid in humans. Prostaglandins, Leukotrienes and Essential Fatty Acids, 75, (3), 161-168. (doi:10.1016/j.plefa.2006.05.013).
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Alpha-linolenic acid (18:3n-3) is essential in the human diet, probably because it is the substrate for the synthesis of longer-chain, more unsaturated n-3 fatty acids eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) which are required for tissue function. This article reviews the recent literature on 18:3n-3 metabolism in humans, including fatty acid beta-oxidation, recycling of carbon by fatty acid synthesis de novo and conversion to longer-chain polyunsaturated fatty acids (PUFA). In men, stable isotope tracer studies and studies in which volunteers increased their consumption of 18:3n-3 show conversion to 20:5n-3 and 22:5n-3, but limited conversion to 22:6n-3. However, conversion to 18:3n-3 to 20:5n-3 and 22:6n-3 is greater in women compared to men, due possibly to a regulatory effect of oestrogen, while partitioning of 18:3n-3 towards beta-oxidation and carbon recycling was lower than in men. These gender differences may be an important consideration in making dietary recommendations for n-3 PUFA intake.
|Additional Information:||Proceedings of the 7th Fatty Acid and Cell Signaling (FACS)workshop held in Paris on September 28-30, 2005.|
|Subjects:||R Medicine > RC Internal medicine|
|Divisions:||University Structure - Pre August 2011 > School of Medicine
|Date Deposited:||30 Sep 2008|
|Last Modified:||06 Aug 2015 02:49|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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