The effect of altering the 20:5n-3 and 22:6n-3 content of a meal on the postprandial incorporation of n-3 polyunsaturated fatty acids into plasma triacylglycerol and non-esterified fatty acids in humans
Burdge, G.C., Sala-Vila, A., West, A.L., Robson, H.J.L., Le Fevre, L.W., Powell, J. and Calder, P.C. (2007) The effect of altering the 20:5n-3 and 22:6n-3 content of a meal on the postprandial incorporation of n-3 polyunsaturated fatty acids into plasma triacylglycerol and non-esterified fatty acids in humans. Prostaglandins, leukotrienes, and essential fatty acids, 77, (1), 59-65. (doi:10.1016/j.plefa.2007.06.003).
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Description/Abstract
Previous studies suggest that consuming meals containing large amounts of fish oil is associated with selective postprandial incorporation of 20:5n-3 and 22:6n-3 into plasma non-esterified fatty acids (NEFA). We investigated the effect of consuming meals containing different amounts of 20:5n-3 and 22:6n-3 comparable to dietary habits of western populations on the postprandial incorporation of 18:3n-3, 20:5n-3 and 22:6n-3 into plasma triacylglycerol (TAG) and NEFA over 6h in middle aged subjects. 20:5n-3 incorporation into plasma TAG was greater than 22:6n-3 irrespective of the test meal. Conversely, 22:6n-3 incorporation into plasma NEFA was greater than 20:5n-3, irrespective of the test meal. There was no effect of the amount of 20:5n-3+22:6n-3 in the test meal on the 18:3n-3 incorporation into plasma TAG or NEFA. These findings suggest differential metabolism of 20:5n-3 and 22:6n-3 in the postprandial period when consumed in amounts typical of western dietary habits.
| Item Type: | Article |
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| Additional Information: | |
| ISSNs: | 0952-3278 (print) |
| Related URLs: | |
| Keywords: | humans, male, aged, human, nutrition, postprandial period, metabolism, blood, middle aged,nonesterified, analysis, docosahexaenoic acids, fatty acids, administration & dosage, triglycerides, time factors,acid, female, fatty acids, eicosapentaenoic acid, sex factors, physiology |
| Subjects: | R Medicine > R Medicine (General) Q Science > QP Physiology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine |
| Item ID: | 60944 |
| Date Deposited: | 23 Sep 2008 |
| Last Modified: | 01 Jun 2011 09:40 |
| Contributors: | Burdge, G.C. (Author) Sala-Vila, A. (Author) West, A.L. (Author) Robson, H.J.L. (Author) Le Fevre, L.W. (Author) Powell, J. (Author) Calder, P.C. (Author) |
| Date: | 10 August 2007 |
| Additional Information: | |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/60944 |
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