The effect of altering the 20:5n-3 and 22:6n-3 content of a meal on the postprandial incorporation of n-3 polyunsaturated fatty acids into plasma triacylglycerol and non-esterified fatty acids in humans
Burdge, G.C., Sala-Vila, A., West, A.L., Robson, H.J.L., Le Fevre, L.W., Powell, J. and Calder, P.C. (2007) The effect of altering the 20:5n-3 and 22:6n-3 content of a meal on the postprandial incorporation of n-3 polyunsaturated fatty acids into plasma triacylglycerol and non-esterified fatty acids in humans. Prostaglandins, leukotrienes, and essential fatty acids, 77, (1), 59-65. (doi:10.1016/j.plefa.2007.06.003).
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Previous studies suggest that consuming meals containing large amounts of fish oil is associated with selective postprandial incorporation of 20:5n-3 and 22:6n-3 into plasma non-esterified fatty acids (NEFA). We investigated the effect of consuming meals containing different amounts of 20:5n-3 and 22:6n-3 comparable to dietary habits of western populations on the postprandial incorporation of 18:3n-3, 20:5n-3 and 22:6n-3 into plasma triacylglycerol (TAG) and NEFA over 6h in middle aged subjects. 20:5n-3 incorporation into plasma TAG was greater than 22:6n-3 irrespective of the test meal. Conversely, 22:6n-3 incorporation into plasma NEFA was greater than 20:5n-3, irrespective of the test meal. There was no effect of the amount of 20:5n-3+22:6n-3 in the test meal on the 18:3n-3 incorporation into plasma TAG or NEFA. These findings suggest differential metabolism of 20:5n-3 and 22:6n-3 in the postprandial period when consumed in amounts typical of western dietary habits.
|Keywords:||humans, male, aged, human, nutrition, postprandial period, metabolism, blood, middle aged,nonesterified, analysis, docosahexaenoic acids, fatty acids, administration & dosage, triglycerides, time factors,acid, female, fatty acids, eicosapentaenoic acid, sex factors, physiology|
|Subjects:||R Medicine > R Medicine (General)
Q Science > QP Physiology
|Divisions:||University Structure - Pre August 2011 > School of Medicine
|Date Deposited:||23 Sep 2008|
|Last Modified:||27 Mar 2014 18:43|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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