The mechanisms and regulation of placental amino acid transport to the human foetus

Cleal, J.K. and Lewis, R.M. (2008) The mechanisms and regulation of placental amino acid transport to the human foetus. Journal of Neuroendocrinology, 20, (4), 419-426. (doi:10.1111/j.1365-2826.2008.01662.x).


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The mechanisms by which amino acids are transferred across the human placenta are fundamental to our understanding of foetal nutrition. Amino acid transfer across the human placenta is dependent on transport across both the microvillous and basal plasma membranes of the placental syncytiotrophoblast, and on metabolism within the syncytiotrophoblast. Although the principles underlying uptake of amino acids across the microvillous plasma membrane are well understood, the extent to which amino acids are metabolised within human placenta and the mechanisms by which amino acids are transported out of the placenta across the basal plasma membrane are not well understood. Understanding the mechanisms and regulation of amino acid transport is necessary to understand the causes of intrauterine growth restriction in human pregnancy.

Item Type: Article
ISSNs: 0953-8194 (print)
Related URLs:
Keywords: amino acid, placenta, transport, foetus, metabolism
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RG Gynecology and obstetrics
Divisions: University Structure - Pre August 2011 > School of Medicine
ePrint ID: 61001
Date Deposited: 25 Sep 2008
Last Modified: 06 Aug 2015 02:49

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