Bone modeling: the first step in the bone-building process

Cole, Z.A. and Cooper, C. (2007) Bone modeling: the first step in the bone-building process. Medicographia, 29, (2), 113-119.


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Osteoporosis is a major cause of morbidity and mortality through its association
with age-related fractures. Although most effort in fracture
prevention has been directed at retarding the rate of age-related bone
loss, and reducing the frequency and severity of trauma among elderly people,
evidence is growing that peak bone mass is an important contributor to bone
strength during later life. Bone mass in later life depends upon the peak attained
during childhood and adolescence, and on the subsequent rate of bone loss. Factors
that influence the accumulation of bone mineral during childhood and adolescence
include heredity, gender, diet, physical activity, endocrine status, and
sporadic risk factors such as cigarette smoking. In addition to modifiable factors
during childhood, evidence has also accrued that fracture risk might be programmed
during intrauterine life. Epidemiological studies have demonstrated
a relationship between birth weight, weight in infancy, and adult bone mass.
This appears to be mediated through modulation of the set-point for basal activity
of pituitary-dependent endocrine systems, such as the hypothalamic-pituitary-
adrenal axis, and the growth hormone/insulin-like growth factor I axis.
Maternal smoking, diet, and physical activity levels appear to modulate bone
mineral acquisition during intrauterine life. Furthermore, both low birth size
and poor childhood growth are directly linked to the later risk of hip fracture.
Optimization of maternal nutrition and intrauterine growth should also be included
in preventive strategies against osteoporotic fracture, albeit for future

Item Type: Article
ISSNs: 0243-3397 (print)
Related URLs:
Keywords: osteoporosis, epidemiology, growth, programming, development
Subjects: R Medicine > RB Pathology
R Medicine > RF Otorhinolaryngology
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 61007
Accepted Date and Publication Date:
Date Deposited: 18 Nov 2008
Last Modified: 31 Mar 2016 12:43

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