The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspring
Cripps, R.L., Green, L.R., Thompson, J., Martin-Gronert, M.S., Monk, M., Sheldon, I.M., Hanson, M.A., Hales, C.N. and Ozanne, S.E. (2008) The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspring. Reproductive Sciences, 15, (5), 448-456. (doi:10.1177/1933719107312161).
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Description/Abstract
This study investigates the effects of diet-induced changes in maternal body condition on glucose tolerance in sheep. Welsh Mountain ewes were established, by dietary manipulation, at a body condition score of 2 (lower body condition [LBCS], n = 17) or >3 (higher body condition [HBCS], n = 19) prior to and during pregnancy. Birth weight and postnatal growth were similar in LBCS and HBCS offspring. In young adulthood, LBCS offspring had increased fasting glucose levels (3.8 +/- 0.07 vs 3.6 +/- 0.05 mM, P < .05), poorer glucose tolerance (2274 +/- 22.6 vs 2161 +/- 33 min/mM, P < .01), and reduced insulin secretion (0.58 +/- 0.05 vs 0.71 +/- 0.07 nM/min, P = .07). Increased fasting glycemia, mild glucose intolerance, and impaired initial insulin secretory response, as observed in LBCS offspring, are indictors of increased diabetes risk in humans. These findings suggest that altered maternal body composition and an imbalance between the fetal and postnatal environment influence offspring glucose tolerance.
| Item Type: | Article |
|---|---|
| ISSNs: | 1933-7191 (print) |
| Related URLs: | |
| Keywords: | diabetes, fetal, pregnancy, risk,adult, tolerance, glucose intolerance, human, birth-weight, weight, adult sheep, glucose tolerance, sheep, insulin, birth weight, research, body-composition, growth, glucose, maternal, body composition, birth, secretion, humans, environment, fasting |
| Subjects: | R Medicine Q Science > QH Natural history > QH301 Biology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine |
| Item ID: | 61027 |
| Date Deposited: | 10 Sep 2008 |
| Last Modified: | 02 Mar 2012 12:12 |
| Contributors: | Cripps, R.L. (Author) Green, L.R. (Author) Thompson, J. (Author) Martin-Gronert, M.S. (Author) Monk, M. (Author) Sheldon, I.M. (Author) Hanson, M.A. (Author) Hales, C.N. (Author) Ozanne, S.E. (Author) |
| Date: | 2008 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/61027 |
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