Commentary: statins and fracture--why the confusion?
Edwards, C.J. and Arden, N.K. (2006) Commentary: statins and fracture--why the confusion? International Journal of Epidemiology, 35, (5), 1312-1313. (doi:10.1093/ije/dyl137).
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In 1999 a paper published in Science suggested that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) increased bone formation in rodents by effects on a potent bone forming cytokine bone morphogenetic protein-2 (BMP-2).1 Subsequent studies have suggested that statins increase bone mineral density (BMD) in humans2 and have investigated whether statin use is associated with reduced fracture risk.
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
|Date Deposited:||08 Sep 2008|
|Last Modified:||01 Jun 2011 05:00|
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