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Commentary: statins and fracture--why the confusion?

Commentary: statins and fracture--why the confusion?
Commentary: statins and fracture--why the confusion?
In 1999 a paper published in Science suggested that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) increased bone formation in rodents by effects on a potent bone forming cytokine bone morphogenetic protein-2 (BMP-2).1 Subsequent studies have suggested that statins increase bone mineral density (BMD) in humans2 and have investigated whether statin use is associated with reduced fracture risk.
editorial, nosp, bone
0300-5771
1312-1313
Edwards, C.J.
f3c756df-8b83-4c2a-9e25-bd4820e75d28
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f
Edwards, C.J.
f3c756df-8b83-4c2a-9e25-bd4820e75d28
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f

Edwards, C.J. and Arden, N.K. (2006) Commentary: statins and fracture--why the confusion? International Journal of Epidemiology, 35 (5), 1312-1313. (doi:10.1093/ije/dyl137).

Record type: Article

Abstract

In 1999 a paper published in Science suggested that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) increased bone formation in rodents by effects on a potent bone forming cytokine bone morphogenetic protein-2 (BMP-2).1 Subsequent studies have suggested that statins increase bone mineral density (BMD) in humans2 and have investigated whether statin use is associated with reduced fracture risk.

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Published date: 2006
Keywords: editorial, nosp, bone

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Local EPrints ID: 61070
URI: http://eprints.soton.ac.uk/id/eprint/61070
ISSN: 0300-5771
PURE UUID: 11ae2f7b-dd29-46a2-b9fe-da853bac21bf

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Date deposited: 08 Sep 2008
Last modified: 15 Mar 2024 11:22

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Author: C.J. Edwards
Author: N.K. Arden

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