The University of Southampton
University of Southampton Institutional Repository

The autoantibody rheumatoid factor may be an independent risk factor for ischaemic heart disease in men.

The autoantibody rheumatoid factor may be an independent risk factor for ischaemic heart disease in men.
The autoantibody rheumatoid factor may be an independent risk factor for ischaemic heart disease in men.
BACKGROUND: Subjects with rheumatoid arthritis have an increased prevalence of ischaemic heart disease (IHD). This is most likely in those people with the autoantibody rheumatoid factor (RF). RF is strongly associated with rheumatoid arthritis (RA) but is also present in up to 15% of all adults.
OBJECTIVE: To determine whether RF might identify people in a general population who also share an increased likelihood of developing IHD.
METHODS: Subjects from the Hertfordshire Cohort Study were investigated for the presence of RF. Subjects completed a questionnaire and attended a clinic where a history of IHD was recorded (ECG, coronary artery bypass grafting, Rose chest pain). Associations between the presence of RF, antinuclear antibodies (ANA), anticardiolipin antibodies (ACA) and IHD in 567 men and 589 women were investigated and compared with traditional risk factors for IHD.
RESULTS: RF was associated with an increased likelihood of IHD in men (odds ratio (OR) = 3.1, 95% CI 1.7 to 5.4, p<0.001). This increased risk could not be explained by traditional risk factors for IHD (mutually adjusted OR for RF 2.9 (95% CI 1.6 to 5.3), p<0.001). There was no significant association between RF in women or between ANA or ACA with IHD in men or women.
CONCLUSION: This work suggests that RF is an independent risk factor for IHD in the general population. It lends support to the importance of inflammation in atherosclerosis and suggests that autoimmune processes may be involved. In addition, it raises the intriguing possibility that RF may have a direct role in the pathogenesis of IHD in some subjects.
disease, prevalence, heart, research, rheumatoid arthritis, male, cohort, cohort studies, methods, middle aged, pain, inflammation, humans, adult, biological markers, cardiovascular disease, epidemiology, risk factors, diagnosis, aged, risk, rheumatoid factor, hertfordshire, enzyme-linked immunosorbent assay, metabolism, female, atherosclerosis, odds ratio, myocardial ischemia, women, coronary artery bypass
1263-1267
Edwards, C.J.
dcb27fec-75ea-4575-a844-3588bcf14106
Syddall, H.
a0181a93-8fc3-4998-a996-7963f0128328
Goswami, R.
64e8d1fe-46a3-4ace-acdd-c6ee900a1087
Goswami, P.
e2b1812a-6f5f-4389-a401-bf7a36fb06ec
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Edwards, C.J.
dcb27fec-75ea-4575-a844-3588bcf14106
Syddall, H.
a0181a93-8fc3-4998-a996-7963f0128328
Goswami, R.
64e8d1fe-46a3-4ace-acdd-c6ee900a1087
Goswami, P.
e2b1812a-6f5f-4389-a401-bf7a36fb06ec
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Edwards, C.J., Syddall, H., Goswami, R., Goswami, P., Dennison, E.M., Arden, N.K. and Cooper, C. (2007) The autoantibody rheumatoid factor may be an independent risk factor for ischaemic heart disease in men. Heart, 93 (10), 1263-1267. (doi:10.1136/hrt.2006.097816).

Record type: Article

Abstract

BACKGROUND: Subjects with rheumatoid arthritis have an increased prevalence of ischaemic heart disease (IHD). This is most likely in those people with the autoantibody rheumatoid factor (RF). RF is strongly associated with rheumatoid arthritis (RA) but is also present in up to 15% of all adults.
OBJECTIVE: To determine whether RF might identify people in a general population who also share an increased likelihood of developing IHD.
METHODS: Subjects from the Hertfordshire Cohort Study were investigated for the presence of RF. Subjects completed a questionnaire and attended a clinic where a history of IHD was recorded (ECG, coronary artery bypass grafting, Rose chest pain). Associations between the presence of RF, antinuclear antibodies (ANA), anticardiolipin antibodies (ACA) and IHD in 567 men and 589 women were investigated and compared with traditional risk factors for IHD.
RESULTS: RF was associated with an increased likelihood of IHD in men (odds ratio (OR) = 3.1, 95% CI 1.7 to 5.4, p<0.001). This increased risk could not be explained by traditional risk factors for IHD (mutually adjusted OR for RF 2.9 (95% CI 1.6 to 5.3), p<0.001). There was no significant association between RF in women or between ANA or ACA with IHD in men or women.
CONCLUSION: This work suggests that RF is an independent risk factor for IHD in the general population. It lends support to the importance of inflammation in atherosclerosis and suggests that autoimmune processes may be involved. In addition, it raises the intriguing possibility that RF may have a direct role in the pathogenesis of IHD in some subjects.

This record has no associated files available for download.

More information

Published date: 2007
Keywords: disease, prevalence, heart, research, rheumatoid arthritis, male, cohort, cohort studies, methods, middle aged, pain, inflammation, humans, adult, biological markers, cardiovascular disease, epidemiology, risk factors, diagnosis, aged, risk, rheumatoid factor, hertfordshire, enzyme-linked immunosorbent assay, metabolism, female, atherosclerosis, odds ratio, myocardial ischemia, women, coronary artery bypass

Identifiers

Local EPrints ID: 61075
URI: http://eprints.soton.ac.uk/id/eprint/61075
PURE UUID: 335f76f1-0975-4573-8293-0c1c743307fd
ORCID for H. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 08 Sep 2008
Last modified: 18 Mar 2024 02:48

Export record

Altmetrics

Contributors

Author: C.J. Edwards
Author: H. Syddall ORCID iD
Author: R. Goswami
Author: P. Goswami
Author: E.M. Dennison ORCID iD
Author: N.K. Arden
Author: C. Cooper ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×