Patterns of growth among children who later develop type 2 diabetes or its risk factors
Eriksson, J.G., Osmond, C., Kajantie, E., Forsen, T.J. and Barker, D.J. (2006) Patterns of growth among children who later develop type 2 diabetes or its risk factors. Diabetologia, 49, (12), 2853-2858. (doi:10.1007/s00125-006-0459-1).
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AIMS/HYPOTHESIS: We studied fetal and childhood growth patterns that are associated with IGT and type 2 diabetes in adult life.
METHODS: We examined clinically 2,003 subjects born in Helsinki between 1934 and 1944. They had on average 11 measurements of height and weight between birth and 2 years of age, and seven measurements between 2 and 11 years of age. Glucose tolerance in adult life was assessed by a 75-g oral glucose tolerance test.
RESULTS: We identified 311 subjects with type 2 diabetes and 496 with IGT. Both IGT and type 2 diabetes were associated with low birthweight (p < 0.0001 adjusting for current BMI). The risk of these conditions was increased by low weight gain between birth and 2 years. A 1 SD increase in weight at 2 years was associated with an odds ratio for either type 2 diabetes or IGT of 0.76 (95% CI 0.69-0.84). This effect was greatest in people who had low birthweight. Low growth in the first 6 months after birth was a critical period for the development of insulin resistance in later life; other critical periods were associated with slow fetal growth and rapid increase in BMI between age 2 and 11 years.
CONCLUSIONS/INTERPRETATION: Low weight gain during infancy increases the risk of IGT and type 2 diabetes. The effect is greater in people who had low birthweight. The first 6 months after birth may be the most critical period for growth, in relation to development of glucose intolerance.
|Digital Object Identifier (DOI):||doi:10.1007/s00125-006-0459-1|
|Keywords:||glucose tolerance test, fetal, weight gain, insulin resistance, diabetes, risk, insulin, glucose tolerance, insulin-resistance, growth, birth, tolerance, adult, odds ratio, glucose intolerance, weight, fetal-growth, risk factors, resistance, childhood, height, development, methods, cardiovascular disease, glucose, later life|
Q Science > QP Physiology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||10 Sep 2008|
|Last Modified:||31 Mar 2016 12:44|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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