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Calcium and vitamin D in the prevention of osteoporotic fractures

Calcium and vitamin D in the prevention of osteoporotic fractures
Calcium and vitamin D in the prevention of osteoporotic fractures
Osteoporosis has been defined as a skeletal disorder characterized by compromised bone strength, predisposing a person to increased risk of fracture. The three major osteoporotic fractures are those of the forearm, vertebra and hip, but fractures of the humerus, pelvis and ribs are also common. The incidence of these fracture rises steeply with age, such that most occur in people aged >65 years, where they are associated with excess mortality, substantial morbidity, and significant health and social services expenditure. This paper outlines the physiological roles of calcium and vitamin D, and assesses the current criteria for adequate calcium intake and optimal vitamin D status in adults. It highlights the prevalence of vitamin D insufficiency and low calcium intake in the UK, and reviews studies of vitamin D supplementation, with and without calcium, in the prevention of falls and fractures.
calcium, fractures, vitamin d, dietary supplements, aged, physiology, administration & dosage, female, 80 and over, Great Britain, osteoporosis, research, vitamin d deficiency, bone, epidemiology, prevention & control, humans, male, dietary, review
1460-2725
355-363
Francis, R.M.
24c83ccf-43d2-4a8d-b3db-7ef2ea0241f7
Anderson, F.H.
ed26ec76-5200-4927-b39a-3f96f8ffeb43
Patel, S.
78768815-0cdc-4ece-afc4-c8cb77fd760d
Sahota, O.
d1c9e181-cd07-4053-b1b8-9f157ed50204
Van Staa, T.P.
31b8bfb4-4e1b-4a48-a5a6-90ca601b94af
Francis, R.M.
24c83ccf-43d2-4a8d-b3db-7ef2ea0241f7
Anderson, F.H.
ed26ec76-5200-4927-b39a-3f96f8ffeb43
Patel, S.
78768815-0cdc-4ece-afc4-c8cb77fd760d
Sahota, O.
d1c9e181-cd07-4053-b1b8-9f157ed50204
Van Staa, T.P.
31b8bfb4-4e1b-4a48-a5a6-90ca601b94af

Francis, R.M., Anderson, F.H., Patel, S., Sahota, O. and Van Staa, T.P. (2006) Calcium and vitamin D in the prevention of osteoporotic fractures. QJM: An International Journal of Medicine, 99 (6), 355-363. (doi:10.1093/qjmed/hcl031).

Record type: Article

Abstract

Osteoporosis has been defined as a skeletal disorder characterized by compromised bone strength, predisposing a person to increased risk of fracture. The three major osteoporotic fractures are those of the forearm, vertebra and hip, but fractures of the humerus, pelvis and ribs are also common. The incidence of these fracture rises steeply with age, such that most occur in people aged >65 years, where they are associated with excess mortality, substantial morbidity, and significant health and social services expenditure. This paper outlines the physiological roles of calcium and vitamin D, and assesses the current criteria for adequate calcium intake and optimal vitamin D status in adults. It highlights the prevalence of vitamin D insufficiency and low calcium intake in the UK, and reviews studies of vitamin D supplementation, with and without calcium, in the prevention of falls and fractures.

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More information

Published date: 2006
Keywords: calcium, fractures, vitamin d, dietary supplements, aged, physiology, administration & dosage, female, 80 and over, Great Britain, osteoporosis, research, vitamin d deficiency, bone, epidemiology, prevention & control, humans, male, dietary, review

Identifiers

Local EPrints ID: 61116
URI: http://eprints.soton.ac.uk/id/eprint/61116
ISSN: 1460-2725
PURE UUID: 5e6a0b48-c4c5-41dc-bad2-59aca735fb55

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Date deposited: 10 Sep 2008
Last modified: 15 Mar 2024 11:24

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Contributors

Author: R.M. Francis
Author: F.H. Anderson
Author: S. Patel
Author: O. Sahota
Author: T.P. Van Staa

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