Developmental plasticity and human disease: research directions

Gluckman, P.D. and Hanson, M.A. (2007) Developmental plasticity and human disease: research directions. Journal of Internal Medicine, 261, (5), 461-471. (doi:10.1111/j.1365-2796.2007.01802.x).


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The conceptual basis of the 'developmental origins' paradigm has converged on the role of developmental plasticity responding to signals from the early environment, with heightened risk of disease if the induced phenotype does not match the later environment. Nevertheless, numerous questions remain, including the current burden of disease that can be attributed to early environmental factors; the pathways, mechanisms and windows of plasticity; the identification of early markers of environmentally induced change; and the feasibility, costs and benefits of intervention. A focused agenda of research is needed to convince policy makers of the importance of developmental factors in human disease.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1111/j.1365-2796.2007.01802.x
ISSNs: 0954-6820 (print)
Related URLs:
Keywords: fetal growth retardation, insulin resistance, leptin, obesity, pregnancy, type 2 diabetes mellitus
Subjects: R Medicine > RG Gynecology and obstetrics
R Medicine > RC Internal medicine
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 61154
Accepted Date and Publication Date:
May 2007Published
Date Deposited: 25 Sep 2008
Last Modified: 31 Mar 2016 12:44

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