Head cooling for neonatal encephalopathy: the state of the art

Gunn, Alistair Jan and Gluckman, Peter D. (2007) Head cooling for neonatal encephalopathy: the state of the art. Clinical Obstetrics & Gynecology, 50, (3), 636-651.


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The possibility that hypothermia started during or after resuscitation at birth might reduce brain damage and cerebral palsy has tantalized clinicians for a long time. The key insight was that transient severe hypoxia-ischemia can precipitate a complex biochemical cascade leading to delayed neuronal loss. There is now strong experimental and clinical evidence that mild to moderate cooling can interrupt this cascade, and improve the number of infants surviving without disability in the medium term. The key remaining issues are to finding better ways of identifying babies who are most likely to benefit, to define the optimal mode and conditions of hypothermia and to find ways to further improve the effectiveness of treatment.

Item Type: Article
ISSNs: 0009-9201 (print)
Related URLs:
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 61186
Accepted Date and Publication Date:
September 2007Published
Date Deposited: 26 Sep 2008
Last Modified: 31 Mar 2016 12:44
URI: http://eprints.soton.ac.uk/id/eprint/61186

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