Parental determinants of neonatal body composition
Parental determinants of neonatal body composition
Background: The prevalence of both childhood and adult obesity is rising in the developed world, and there is increasing interest in its underlying causes. A number of studies suggest a positive relationship between birth weight and childhood body mass index, but less is known about specific prenatal environmental influences on more direct measures of obesity. We used data from the Southampton Women's Survey to investigate parental influences on neonatal body composition ascertained by dual x-ray absorptiometry.
Methods: Participating mothers were characterized in detail (anthropometry, lifestyle, diet) before and during pregnancy; information was also obtained on their partners. The offspring underwent assessment of fat and lean body mass by dual x-ray absorptiometry within 2 wk of birth. Linear regression methods were used to explore the parental determinants of neonatal body composition.
Results: Complete data were available for 448 mother-offspring pairs. Taller women and those with higher parity had offspring with increased birth weight, fat, and lean mass (P < 0.05). Mothers who were taller, of greater parity, had greater fat stores, or walked more slowly also had offspring with greater proportionate body fat at birth (all P < 0.05). There was a weaker trend toward lower percentage fat and greater percentage lean in the offspring of mothers who smoked during pregnancy.
Conclusion: Maternal size, parity, smoking history, walking speed, and fat stores are independent determinants of neonatal body composition. If these influences are shown to have persisting effects on body composition through to adulthood, they point to novel public health interventions early in life to prevent later obesity
523-526
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Poole, J.R.
9e7d4389-cddd-46bf-add2-bd6225538897
Javaid, Muhammad K.
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Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Robinson, Sian
ba591c98-4380-456a-be8a-c452f992b69b
Inskip, Hazel M.
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Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sayer, Aihie A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
2007
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Poole, J.R.
9e7d4389-cddd-46bf-add2-bd6225538897
Javaid, Muhammad K.
96dface0-b6e3-47f0-8365-7f22f33a2022
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Robinson, Sian
ba591c98-4380-456a-be8a-c452f992b69b
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sayer, Aihie A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Harvey, Nicholas C., Poole, J.R., Javaid, Muhammad K., Dennison, Elaine M., Robinson, Sian, Inskip, Hazel M., Godfrey, Keith M., Cooper, Cyrus and Sayer, Aihie A.
(2007)
Parental determinants of neonatal body composition.
Journal of Clinical Endocrinology & Metabolism, 92 (2), .
(doi:10.1210/jc.2006-0456).
Abstract
Background: The prevalence of both childhood and adult obesity is rising in the developed world, and there is increasing interest in its underlying causes. A number of studies suggest a positive relationship between birth weight and childhood body mass index, but less is known about specific prenatal environmental influences on more direct measures of obesity. We used data from the Southampton Women's Survey to investigate parental influences on neonatal body composition ascertained by dual x-ray absorptiometry.
Methods: Participating mothers were characterized in detail (anthropometry, lifestyle, diet) before and during pregnancy; information was also obtained on their partners. The offspring underwent assessment of fat and lean body mass by dual x-ray absorptiometry within 2 wk of birth. Linear regression methods were used to explore the parental determinants of neonatal body composition.
Results: Complete data were available for 448 mother-offspring pairs. Taller women and those with higher parity had offspring with increased birth weight, fat, and lean mass (P < 0.05). Mothers who were taller, of greater parity, had greater fat stores, or walked more slowly also had offspring with greater proportionate body fat at birth (all P < 0.05). There was a weaker trend toward lower percentage fat and greater percentage lean in the offspring of mothers who smoked during pregnancy.
Conclusion: Maternal size, parity, smoking history, walking speed, and fat stores are independent determinants of neonatal body composition. If these influences are shown to have persisting effects on body composition through to adulthood, they point to novel public health interventions early in life to prevent later obesity
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Published date: 2007
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Local EPrints ID: 61203
URI: http://eprints.soton.ac.uk/id/eprint/61203
ISSN: 0021-972X
PURE UUID: fecb730e-c5c8-41bd-ae15-04fac74ca93d
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Date deposited: 12 Sep 2008
Last modified: 18 Mar 2024 02:58
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Author:
J.R. Poole
Author:
Muhammad K. Javaid
Author:
Sian Robinson
Author:
Aihie A. Sayer
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