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Paternal skeletal size predicts intrauterine bone mineral accrual

Paternal skeletal size predicts intrauterine bone mineral accrual
Paternal skeletal size predicts intrauterine bone mineral accrual
Background: We have previously demonstrated that maternal body build and lifestyle factors predict neonatal bone mineral accrual. However, the paternal determinants of neonatal bone mass are not known. In this study we explored the relationship between a father's bone mass and that of his offspring.

Methods: A total of 278 pregnancies (142 male and 136 female neonates) were recruited from the Southampton Women's Survey, a unique, well-established cohort of women, aged 20-34 yr, who had been assessed before and during pregnancy. The neonates and their fathers underwent whole body dual-x-ray absorptiometry (DXA) within 2 wk of birth using a Lunar DPX (General Electric Corp., Madison, WI) and Hologic Discovery instrument (Hologic Inc., Bedford, MA), respectively; correlation and regression methods were used to explore the parental determinants of neonatal bone mass.

Results: After adjusting the paternal DXA indices for father's age and the neonatal for baby's gestational age and age at DXA scan, there were highly significant positive associations between baby's whole body bone area, bone mineral content, and bone mineral density and the corresponding indices in the father (P = 0.003, 0.0002, 0.046, respectively) among female infants. These relationships were independent of maternal height and fat stores. The associations for male infants with paternal DXA indices did not achieve statistical significance.

Conclusions: The father's skeletal size predicts skeletal size more strongly in female than male offspring, independently of the mother's body build. These data point toward the importance of considering paternal genotype in studies exploring the developmental origins of osteoporotic fracture and raise intriguing mechanistic questions about the gender specificity of influences on intrauterine bone mineral accrual
developmental origins, bone, female, pregnancy, methods, gestational age, infant, genotype, bone mass, cohort, male, mass, height, birth, fathers, size, maternal, women, aged, origins, gender, research
0021-972X
1676-1681
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Javaid, M.K.
51d3310b-032e-4c15-83ac-b878bce090f3
Poole, J.R.
9e7d4389-cddd-46bf-add2-bd6225538897
Taylor, P.
28b91e71-fad2-4375-8a1e-535f861901c3
Robinson, S.M.
ba591c98-4380-456a-be8a-c452f992b69b
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Javaid, M.K.
51d3310b-032e-4c15-83ac-b878bce090f3
Poole, J.R.
9e7d4389-cddd-46bf-add2-bd6225538897
Taylor, P.
28b91e71-fad2-4375-8a1e-535f861901c3
Robinson, S.M.
ba591c98-4380-456a-be8a-c452f992b69b
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1

Harvey, N.C., Javaid, M.K., Poole, J.R., Taylor, P., Robinson, S.M., Inskip, H.M., Godfrey, K.M., Cooper, C. and Dennison, E.M. (2008) Paternal skeletal size predicts intrauterine bone mineral accrual. Journal of Clinical Endocrinology & Metabolism, 93 (5), 1676-1681. (doi:10.1210/jc.2007-0279).

Record type: Article

Abstract

Background: We have previously demonstrated that maternal body build and lifestyle factors predict neonatal bone mineral accrual. However, the paternal determinants of neonatal bone mass are not known. In this study we explored the relationship between a father's bone mass and that of his offspring.

Methods: A total of 278 pregnancies (142 male and 136 female neonates) were recruited from the Southampton Women's Survey, a unique, well-established cohort of women, aged 20-34 yr, who had been assessed before and during pregnancy. The neonates and their fathers underwent whole body dual-x-ray absorptiometry (DXA) within 2 wk of birth using a Lunar DPX (General Electric Corp., Madison, WI) and Hologic Discovery instrument (Hologic Inc., Bedford, MA), respectively; correlation and regression methods were used to explore the parental determinants of neonatal bone mass.

Results: After adjusting the paternal DXA indices for father's age and the neonatal for baby's gestational age and age at DXA scan, there were highly significant positive associations between baby's whole body bone area, bone mineral content, and bone mineral density and the corresponding indices in the father (P = 0.003, 0.0002, 0.046, respectively) among female infants. These relationships were independent of maternal height and fat stores. The associations for male infants with paternal DXA indices did not achieve statistical significance.

Conclusions: The father's skeletal size predicts skeletal size more strongly in female than male offspring, independently of the mother's body build. These data point toward the importance of considering paternal genotype in studies exploring the developmental origins of osteoporotic fracture and raise intriguing mechanistic questions about the gender specificity of influences on intrauterine bone mineral accrual

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More information

Published date: 2008
Keywords: developmental origins, bone, female, pregnancy, methods, gestational age, infant, genotype, bone mass, cohort, male, mass, height, birth, fathers, size, maternal, women, aged, origins, gender, research

Identifiers

Local EPrints ID: 61204
URI: http://eprints.soton.ac.uk/id/eprint/61204
ISSN: 0021-972X
PURE UUID: 55f895bf-71cb-4a32-9fba-2d5cb0e3a0c8
ORCID for N.C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for S.M. Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for H.M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961

Catalogue record

Date deposited: 10 Sep 2008
Last modified: 18 Mar 2024 02:58

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Contributors

Author: N.C. Harvey ORCID iD
Author: M.K. Javaid
Author: J.R. Poole
Author: P. Taylor
Author: S.M. Robinson ORCID iD
Author: H.M. Inskip ORCID iD
Author: K.M. Godfrey ORCID iD
Author: C. Cooper ORCID iD
Author: E.M. Dennison ORCID iD

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