Intraperitoneal transfusion in severe, early-onset rh isoimmunization
Intraperitoneal transfusion in severe, early-onset rh isoimmunization
OBJECTIVE: To describe the management of five women with severe, early-onset Rh isoimmunization with a series of intraperitoneal transfusions. METHODS: Intraperitoneal transfusions were started at 15 to 16 weeks of pregnancy, with small volumes of blood given weekly until the umbilical cord could be successfully entered and further transfusions given intravascularly. RESULTS: The initial range of anti-D immune globulin levels was 24-244 international units, and all women had severe Rh isoimmunization complicating previous pregnancies. No fetus was severely anemic at the first intravascular transfusion (lowest hemoglobin 8.9g/dL), and there were no fetal losses. Middle cerebral artery peak systolic velocity responded to treatment with intraperitoneal transfusions, suggesting that even at 15 to 16 weeks of gestation it correlates with fetal hemoglobin. CONCLUSION: This series shows that intraperitoneal transfusions can be used to successfully treat severe, early-onset Rhesus disease. LEVEL OF EVIDENCE: III
methods, pregnancy, fetus, maternal, blood, women, disease, fetal, umbilical cord
880-884
Howe, D.T.
2aff7e22-c75f-4d98-b8af-fe3e1a3d2dcb
Michailidis, G.D.
a830b108-cc28-478a-90b3-d71b3b695d48
2007
Howe, D.T.
2aff7e22-c75f-4d98-b8af-fe3e1a3d2dcb
Michailidis, G.D.
a830b108-cc28-478a-90b3-d71b3b695d48
Howe, D.T. and Michailidis, G.D.
(2007)
Intraperitoneal transfusion in severe, early-onset rh isoimmunization.
Obstetrics & Gynecology, 110 (4), .
Abstract
OBJECTIVE: To describe the management of five women with severe, early-onset Rh isoimmunization with a series of intraperitoneal transfusions. METHODS: Intraperitoneal transfusions were started at 15 to 16 weeks of pregnancy, with small volumes of blood given weekly until the umbilical cord could be successfully entered and further transfusions given intravascularly. RESULTS: The initial range of anti-D immune globulin levels was 24-244 international units, and all women had severe Rh isoimmunization complicating previous pregnancies. No fetus was severely anemic at the first intravascular transfusion (lowest hemoglobin 8.9g/dL), and there were no fetal losses. Middle cerebral artery peak systolic velocity responded to treatment with intraperitoneal transfusions, suggesting that even at 15 to 16 weeks of gestation it correlates with fetal hemoglobin. CONCLUSION: This series shows that intraperitoneal transfusions can be used to successfully treat severe, early-onset Rhesus disease. LEVEL OF EVIDENCE: III
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Published date: 2007
Keywords:
methods, pregnancy, fetus, maternal, blood, women, disease, fetal, umbilical cord
Organisations:
Dev Origins of Health & Disease
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Local EPrints ID: 61236
URI: http://eprints.soton.ac.uk/id/eprint/61236
ISSN: 0029-7844
PURE UUID: bac4e29b-7cdf-4f9a-979f-7293bc345cfb
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Date deposited: 12 Sep 2008
Last modified: 08 Jan 2022 16:03
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Author:
D.T. Howe
Author:
G.D. Michailidis
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