Birth weight and cardiac structure in children


Jiang, Benyu, Godfrey, Keith M., Martyn, Christopher N. and Gale, Catharine R. (2006) Birth weight and cardiac structure in children. Pediatrics, 117, (2), e257-e261. (doi:10.1542/peds.2005-1325).

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Original Publication URL: http://dx.doi.org/10.1542/peds.2005-1325

Description/Abstract

OBJECTIVE: Epidemiologic studies have shown associations between impaired fetal growth and risk for coronary heart disease in adults. The underlying mechanisms are unknown. We investigated whether restricted intrauterine growth affects cardiac structure. METHODS: We performed echocardiography on 216 9-year-old children who were measured previously at birth. The diameter of the coronary left and right main branches was derived from the widest dimension; total coronary artery diameter was calculated by adding the diameters of the left and right coronary arteries. Aortic root diameter, left atrial diameter, left ventricular diameter, left ventricular outflow tract diameter, and left ventricular mass were measured. RESULTS: On average, children who had weighed less at birth had a smaller total coronary artery diameter, aortic root diameter, and left ventricular outflow tract diameter after adjustment for gender, gestational age, current height and weight, and maternal height and prepregnant weight. For each SD increase in birth weight, total coronary diameter rose by 0.10 mm, log aortic root diameter rose by 1.5%, and log left ventricular outflow tract diameter rose by 1.6%. CONCLUSION: Impaired fetal growth may have long-term effects on cardiac structure. This may help to explain why adults whose birth weight was low are at greater risk for coronary heart disease.

Item Type: Article
ISSNs: 0031-4005 (print)
Related URLs:
Keywords: adult, disease, risk, weight, anatomy & histology, aorta, fetal, intrauterine growth, heart, left ventricular mass, mass, birth, gestational age, gender, research support, fetal-growth, coronary vessels, infant, female, coronary heart disease, birth-weight, growth, male, methods, echocardiography, birth weight, child, humans, newborn, coronary-heart-disease, maternal, cardiovascular disease, height
Subjects: R Medicine > RJ Pediatrics
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 61251
Date Deposited: 01 Apr 2009
Last Modified: 27 Mar 2014 18:43
URI: http://eprints.soton.ac.uk/id/eprint/61251

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