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Systemic infections after acute stroke

Systemic infections after acute stroke
Systemic infections after acute stroke
After an acute stroke, systemic infection can complicate the recovery process and lead to a worse clinical outcome, including a higher risk of mortality. Post-stroke infection (PSI) is responsible for the majority of the mortality occurring between 1 week and 1 month after stroke, peaking towards the end of the second week. The effects of PSI on longer-term outcome and other aspects of recovery, such as cognition, mood and quality of life, are largely unknown. The cerebrovascular event itself may result in a systemic immunosuppressed state, hence lowering the threshold for subsequent systemic bacterial infections. Although there have been advances in the basic understanding of the pathophysiological mechanisms of PSI, clinical studies have not provided any clear guidelines on the best methods of managing or preventing PSI. This article provides a review of the current knowledge of the phenomenon of PSI and the possible future developments in the understanding and treatment of PSI.
infection, stroke
1745-5103
85-94
Kwan, Joseph
2f6e316b-60bc-48a4-8b96-464b965ea6a5
Jenkinson, Damian
43e842b8-bb66-4f94-a35e-8f9dec5e8fc4
Vassallo, Mike
3f3ca3a6-0911-468b-9b47-37be8a400691
Englyst, Nicola
f84399af-7265-4224-b556-102c3aa272b0
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Kwan, Joseph
2f6e316b-60bc-48a4-8b96-464b965ea6a5
Jenkinson, Damian
43e842b8-bb66-4f94-a35e-8f9dec5e8fc4
Vassallo, Mike
3f3ca3a6-0911-468b-9b47-37be8a400691
Englyst, Nicola
f84399af-7265-4224-b556-102c3aa272b0
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4

Kwan, Joseph, Jenkinson, Damian, Vassallo, Mike, Englyst, Nicola and Perry, V. Hugh (2008) Systemic infections after acute stroke. Aging Health, 4 (1), 85-94. (doi:10.2217/1745509X.4.1.85).

Record type: Article

Abstract

After an acute stroke, systemic infection can complicate the recovery process and lead to a worse clinical outcome, including a higher risk of mortality. Post-stroke infection (PSI) is responsible for the majority of the mortality occurring between 1 week and 1 month after stroke, peaking towards the end of the second week. The effects of PSI on longer-term outcome and other aspects of recovery, such as cognition, mood and quality of life, are largely unknown. The cerebrovascular event itself may result in a systemic immunosuppressed state, hence lowering the threshold for subsequent systemic bacterial infections. Although there have been advances in the basic understanding of the pathophysiological mechanisms of PSI, clinical studies have not provided any clear guidelines on the best methods of managing or preventing PSI. This article provides a review of the current knowledge of the phenomenon of PSI and the possible future developments in the understanding and treatment of PSI.

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More information

Published date: February 2008
Keywords: infection, stroke

Identifiers

Local EPrints ID: 61309
URI: http://eprints.soton.ac.uk/id/eprint/61309
ISSN: 1745-5103
PURE UUID: bc595950-6946-4f26-8999-f99bac9b2a10
ORCID for Nicola Englyst: ORCID iD orcid.org/0000-0003-0508-8323

Catalogue record

Date deposited: 30 Sep 2008
Last modified: 16 Mar 2024 03:14

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Contributors

Author: Joseph Kwan
Author: Damian Jenkinson
Author: Mike Vassallo
Author: Nicola Englyst ORCID iD
Author: V. Hugh Perry

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