Maternal nutrition during gestation and carotid arterial compliance in the adult offspring: the Dutch famine birth cohort
Painter, Rebecca C., de Rooij, Susanne R., Bossuyt, Patrick M., de Groot, Eric, Stok, Wim J., Osmond, Clive, Barker, David J., Bleker, Otto P. and Roseboom, Tessa J. (2007) Maternal nutrition during gestation and carotid arterial compliance in the adult offspring: the Dutch famine birth cohort. Journal of Hypertension, 25, (3), 533-540.
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OBJECTIVE: Experimental evidence indicates that maternal undernutrition during gestation may program hypertension in the offspring. We investigated whether maternal undernutrition leads to increased arterial stiffness. METHODS: We measured carotid artery lumen diameter (LD), distensibility (DC), stiffness (beta), and compliance (CC) by M-mode ultrasound in 673 individuals, aged 56-61 years, who had been born as term singletons around the time of the 1944-45 Dutch famine. RESULTS: Maternal famine exposure had no effect on any of the measures of carotid size or stiffness in the offspring. Low maternal weight at the end of pregnancy and low birth weight were associated with decreased LD (0.01 mm/kg maternal weight, sex-adjusted P < 0.001; 0.1 mm/kg birth weight, sex-adjusted P = 0.08) and CC (0.002 mm/kPa per kg maternal weight, sex-adjusted P = 0.001; 0.03 mm/kPa per kg birth weight, sex-adjusted P = 0.03), but neither was associated with increased beta, or decreased DC. These effects were not attenuated by adjusting for maternal protein/carbohydrate ratio in the third trimester. The association of low birth weight with increased CC diminished after adjusting for maternal weight. The association of maternal weight with CC was smaller when adjusted for LD. CONCLUSION: Our findings suggest that small maternal size, not poor maternal diet, in late gestation programs decreased arterial compliance in the adult offspring by affecting vessel size rather than vessel wall stiffness.
|Subjects:||R Medicine > RG Gynecology and obstetrics
R Medicine > RA Public aspects of medicine
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||01 Oct 2008|
|Last Modified:||01 Jun 2011 07:22|
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