Effect of iron supplementation on physical growth in children: systematic review of randomised controlled trials
Sachdev, H.P.S., Gera, Tarun and Nestel, Penelope (2006) Effect of iron supplementation on physical growth in children: systematic review of randomised controlled trials. Public Health Nutrition, 9, (7), 904-920. (doi:10.1017/PHN2005918).
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OBJECTIVE: To evaluate the effect of iron supplementation on physical growth in children through a systematic review of randomised controlled trials (RCTs). DATA SOURCES: Electronic databases, personal files, and hand search of reviews, bibliographies of books, abstracts and proceedings of international conferences. REVIEW METHODS: RCTs evaluating change in anthropometry with interventions that included oral or parenteral iron supplementation, or iron-fortified formula milk or cereals, were analysed. RESULTS: Twenty-five trials (26 cohorts) had relevant information. There was no evidence of publication bias. The pooled estimates (random effects model) did not document a statistically significant (P>0.05) positive effect of iron supplementation on any anthropometric variable (weight-for-age, weight-for-height, height-for-age, mid upper-arm circumference, skinfold thickness, head circumference). Significant heterogeneity was evident, and its predictors included greater weight-for-age in supplemented children in malaria hyperendemic regions and greater weight-for-height for children above 5 years of age, but a negative effect on linear growth in developed countries and with supplementation for 6 months or longer. CONCLUSIONS: This review did not document a positive effect of iron supplementation on the physical growth of children. The identified predictors of heterogeneity should be considered as exploratory and requiring confirmation, not conclusive.
|Digital Object Identifier (DOI):||doi:10.1017/PHN2005918|
|Keywords:||anaemia, anthropometry, growth, height-for-age, iron deficiency, iron supplementation, meta-analysis, randomised controlled trials, weight-for-age, weight-for-height|
|Subjects:||R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
|Divisions :||University Structure - Pre August 2011 > School of Medicine
|Accepted Date and Publication Date:||
|Date Deposited:||02 Oct 2008|
|Last Modified:||31 Mar 2016 12:44|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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