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Osteoporosis: trends in epidemiology, pathogenesis and treatment

Osteoporosis: trends in epidemiology, pathogenesis and treatment
Osteoporosis: trends in epidemiology, pathogenesis and treatment
Osteoporosis is a serious public health issue. The past 10 years have seen great advances in our understanding of its epidemiology, pathophysiology, and treatment, and further advances are rapidly being made. Clinical assessment will probably evolve from decisions mainly being made on the basis of bone densitometry, to use of algorithms of absolute fracture risk. Biochemical markers of bone turnover are also likely to become more widely used. Bisphosphonates will probably remain the mainstay of therapy, but improved understanding of the optimum amount of remodelling suppression and duration of therapy will be important. At the same time, other diagnostic and therapeutic approaches, including biological agents, are likely to become more widespread.
calcium, physiology, drug therapy, bone, osteoporosis, densitometry, physiopathology, fractures, vitamin d, complications, public health, bone density, health, bone density conservation agents, epidemiology, time, therapeutic use, trends, drug effects, middle aged, review, bone remodeling, therapy, risk, humans, diphosphonates, female, algorithms, aged, etiology, risk factors
0140-6736
2010-2018
Sambrook, P.
17fed862-0ad3-4bb9-8e6d-1474e8308da5
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sambrook, P.
17fed862-0ad3-4bb9-8e6d-1474e8308da5
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Sambrook, P. and Cooper, C. (2006) Osteoporosis: trends in epidemiology, pathogenesis and treatment. The Lancet, 367 (9527), 2010-2018. (doi:10.1016/S0140-6736(06)68891-0).

Record type: Article

Abstract

Osteoporosis is a serious public health issue. The past 10 years have seen great advances in our understanding of its epidemiology, pathophysiology, and treatment, and further advances are rapidly being made. Clinical assessment will probably evolve from decisions mainly being made on the basis of bone densitometry, to use of algorithms of absolute fracture risk. Biochemical markers of bone turnover are also likely to become more widely used. Bisphosphonates will probably remain the mainstay of therapy, but improved understanding of the optimum amount of remodelling suppression and duration of therapy will be important. At the same time, other diagnostic and therapeutic approaches, including biological agents, are likely to become more widespread.

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More information

Published date: 2006
Keywords: calcium, physiology, drug therapy, bone, osteoporosis, densitometry, physiopathology, fractures, vitamin d, complications, public health, bone density, health, bone density conservation agents, epidemiology, time, therapeutic use, trends, drug effects, middle aged, review, bone remodeling, therapy, risk, humans, diphosphonates, female, algorithms, aged, etiology, risk factors
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 61491
URI: http://eprints.soton.ac.uk/id/eprint/61491
ISSN: 0140-6736
PURE UUID: 9b8ef7e6-12ca-48ff-b361-f82e903fe06a
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 05 Sep 2008
Last modified: 18 Mar 2024 02:44

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Contributors

Author: P. Sambrook
Author: C. Cooper ORCID iD

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