The University of Southampton
University of Southampton Institutional Repository

Development of the Qualeffo-31, an osteoporosis-specific quality-of-life questionnaire

Development of the Qualeffo-31, an osteoporosis-specific quality-of-life questionnaire
Development of the Qualeffo-31, an osteoporosis-specific quality-of-life questionnaire
Introduction: Vertebral deformities are a common consequence of osteoporosis and are known to decrease quality of life. The Qualeffo-41 is a quality-of-life questionnaire especially developed for measuring quality of life in patients with vertebral deformities. It consists of 41 questions arranged in five domains: pain, physical function, social function, general health perception, and mental function. The objectives of this study were: (1) to develop a shorter version of the Qualeffo-41 by removing redundant questions; and (2) to investigate the scale characteristics, reliability, and validity of this shorter version.

Methods: The study was performed using data from the Qualeffo validation study and the Multiple Outcomes of Raloxifene Evaluation (MORE) study. The analyses were performed in patients with vertebral deformities (n=579). Factor analysis on polychoric correlations and an item response theory (IRT) model, i.e., the generalized partial credit model (GPCM), were used to create a shorter version of Qualeffo-41. Using GPCM, scoring weights were computed for all items.

Results: Three items were removed from the data set because of too many missing values. Factor analysis identified three instead of five domains: (1) pain, (2) physical function, and (3) mental function. Five items had factor loadings /=0.95) with the corresponding domains of the Qualeffo-41.

Conclusions: Qualeffo-31 was developed, consisting of three domains with a reasonable to excellent fit to the GPCM. Although the fit to the GPCM supports the construct validity of the Qualeffo-31, validation in a new study should be performed before using it in practice.
function, validity, quality of life, methods, osteoporosis, pain, bone, development, analysis, weight, health
0937-941X
543-551
Van Schoor, N.M.
54108e9a-d965-45e0-86a2-a5eccb7f2890
Knol, D.L.
8a12543c-0cf2-4fb7-8be9-358ec28272a2
Glas, C.A.
49aad885-950d-4823-9dbb-c7577f6f8127
Ostelo, R.W.
cd6eea16-500a-4753-819f-6098c0338ea3
Leplege, A.
7143d356-2023-420f-9cdf-608a1ee9ecb7
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Johnell, O.
633a35fb-6cd3-4df2-af7f-36303f64cf7a
Lips, P.
c17c31d2-f4d8-457f-99ad-fa5af27723ca
Van Schoor, N.M.
54108e9a-d965-45e0-86a2-a5eccb7f2890
Knol, D.L.
8a12543c-0cf2-4fb7-8be9-358ec28272a2
Glas, C.A.
49aad885-950d-4823-9dbb-c7577f6f8127
Ostelo, R.W.
cd6eea16-500a-4753-819f-6098c0338ea3
Leplege, A.
7143d356-2023-420f-9cdf-608a1ee9ecb7
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Johnell, O.
633a35fb-6cd3-4df2-af7f-36303f64cf7a
Lips, P.
c17c31d2-f4d8-457f-99ad-fa5af27723ca

Van Schoor, N.M., Knol, D.L., Glas, C.A., Ostelo, R.W., Leplege, A., Cooper, Cyrus, Johnell, O. and Lips, P. (2006) Development of the Qualeffo-31, an osteoporosis-specific quality-of-life questionnaire. Osteoporosis International, 17 (4), 543-551. (doi:10.1007/s00198-005-0024-7).

Record type: Article

Abstract

Introduction: Vertebral deformities are a common consequence of osteoporosis and are known to decrease quality of life. The Qualeffo-41 is a quality-of-life questionnaire especially developed for measuring quality of life in patients with vertebral deformities. It consists of 41 questions arranged in five domains: pain, physical function, social function, general health perception, and mental function. The objectives of this study were: (1) to develop a shorter version of the Qualeffo-41 by removing redundant questions; and (2) to investigate the scale characteristics, reliability, and validity of this shorter version.

Methods: The study was performed using data from the Qualeffo validation study and the Multiple Outcomes of Raloxifene Evaluation (MORE) study. The analyses were performed in patients with vertebral deformities (n=579). Factor analysis on polychoric correlations and an item response theory (IRT) model, i.e., the generalized partial credit model (GPCM), were used to create a shorter version of Qualeffo-41. Using GPCM, scoring weights were computed for all items.

Results: Three items were removed from the data set because of too many missing values. Factor analysis identified three instead of five domains: (1) pain, (2) physical function, and (3) mental function. Five items had factor loadings /=0.95) with the corresponding domains of the Qualeffo-41.

Conclusions: Qualeffo-31 was developed, consisting of three domains with a reasonable to excellent fit to the GPCM. Although the fit to the GPCM supports the construct validity of the Qualeffo-31, validation in a new study should be performed before using it in practice.

This record has no associated files available for download.

More information

Published date: 2006
Keywords: function, validity, quality of life, methods, osteoporosis, pain, bone, development, analysis, weight, health

Identifiers

Local EPrints ID: 61575
URI: http://eprints.soton.ac.uk/id/eprint/61575
ISSN: 0937-941X
PURE UUID: 6ef0e445-387f-4f3b-8417-3f746b90de5b
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 09 Sep 2008
Last modified: 18 Mar 2024 02:44

Export record

Altmetrics

Contributors

Author: N.M. Van Schoor
Author: D.L. Knol
Author: C.A. Glas
Author: R.W. Ostelo
Author: A. Leplege
Author: Cyrus Cooper ORCID iD
Author: O. Johnell
Author: P. Lips

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×