Lithium use and the risk of fractures
Lithium use and the risk of fractures
A recent study reported a decreased risk of fractures among lithium users. We conducted a case-control study within the UK General Practice Research Database, comparing never, ever, current, recent and past lithium use in 231,778 fracture cases to matched controls. In addition, the risk of fractures was assessed in relation to cumulative duration of use and time since discontinuation. Current use of lithium was associated with a decreased risk of fractures (adjusted odds ratio [OR]=0.75, 95% confidence interval [CI]=0.64-0.88), which did not vary with cumulative duration of use. Among past users an increased risk of fractures was observed (adjusted OR=1.35, 95% CI=1.01-1.79), increasing with time since discontinuation. Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use.
mental disorders, research, risk, bone, fractures, odds ratio, case-control studies
1252-1258
Wilting, I.
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De Vries, F.
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Thio, B.M.
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Cooper, C.
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Heerdink, E.R.
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Leufkens, H.G.
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Nolen, W.A.
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Egberts, A.C.
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Van Staa, T.P.
31b8bfb4-4e1b-4a48-a5a6-90ca601b94af
2007
Wilting, I.
af787556-2191-4907-a14e-087120f9d63b
De Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613
Thio, B.M.
945035ac-0178-46d0-b849-1eb590f42e5e
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Heerdink, E.R.
4668cb6e-b777-4b39-8214-5327a38cde62
Leufkens, H.G.
6f387677-0ec5-408b-bdbc-7a50d49631b6
Nolen, W.A.
b1f24f88-25bd-4a34-86fd-94009ce75ff7
Egberts, A.C.
0dc1505e-b449-495a-b845-29ef8bdd4ae3
Van Staa, T.P.
31b8bfb4-4e1b-4a48-a5a6-90ca601b94af
Wilting, I., De Vries, F., Thio, B.M., Cooper, C., Heerdink, E.R., Leufkens, H.G., Nolen, W.A., Egberts, A.C. and Van Staa, T.P.
(2007)
Lithium use and the risk of fractures.
Bone, 40 (5), .
(doi:10.1016/j.bone.2006.12.055).
Abstract
A recent study reported a decreased risk of fractures among lithium users. We conducted a case-control study within the UK General Practice Research Database, comparing never, ever, current, recent and past lithium use in 231,778 fracture cases to matched controls. In addition, the risk of fractures was assessed in relation to cumulative duration of use and time since discontinuation. Current use of lithium was associated with a decreased risk of fractures (adjusted odds ratio [OR]=0.75, 95% confidence interval [CI]=0.64-0.88), which did not vary with cumulative duration of use. Among past users an increased risk of fractures was observed (adjusted OR=1.35, 95% CI=1.01-1.79), increasing with time since discontinuation. Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use.
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Published date: 2007
Keywords:
mental disorders, research, risk, bone, fractures, odds ratio, case-control studies
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Local EPrints ID: 61612
URI: http://eprints.soton.ac.uk/id/eprint/61612
ISSN: 8756-3282
PURE UUID: ce6f7f66-1435-45aa-a4e9-b169425db756
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Date deposited: 03 Sep 2008
Last modified: 18 Mar 2024 02:44
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Contributors
Author:
I. Wilting
Author:
F. De Vries
Author:
B.M. Thio
Author:
E.R. Heerdink
Author:
H.G. Leufkens
Author:
W.A. Nolen
Author:
A.C. Egberts
Author:
T.P. Van Staa
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