Evaluating the efficacy of acupuncture in defined aspects of stroke recovery: a randomised, placebo controlled single blind study

Hopwood, V., Lewith, G., Prescott, P. and Campbell, M.J. (2008) Evaluating the efficacy of acupuncture in defined aspects of stroke recovery: a randomised, placebo controlled single blind study. Journal of Neurology, 255, (6), 858-866. (doi:10.1007/s00415-008-0790-1).


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Objective To investigate the efficacy of acupuncture on stroke recovery compared to an inert placebo.
Design Placebo-controlled, randomised, clinical trial.
Setting Post-stroke rehabilitation wards in five NHS hospitals in the UK.
Subjects Patients between 4 and 10 days after their first stroke.
Interventions and outcome measures The patients received 12 acupuncture or placebo treatments over four weeks. Acupuncture with electrical stimulation was compared with mock TENS, and assessments continued for 12 months after entry. Primary outcome was the Barthel Index (BI). Secondary outcomes were muscle power, Motricity Index (MI), mood, Nottingham Health Profile (NHP) and treatment credibility.
Results 92 patients completed data sets. Data were analysed using both t tests and a structural equation based on longitudinal analysis of both BI and MI, using generalised estimating equations with an exchangeable correlation structure. While both acupuncture and placebo (mock TENS) appeared to have had an equal effect on stroke recovery, there is no significant difference between the two interventions at 12 (p = 0.737, 95 % CI –2.00 to 2.81) and 52 weeks (p = 0.371, 95 % CI –3.48 to1.32). An apparently accelerated improvement in the MI scores in the acupuncture group at 3 weeks (p = 0.009, 95 % CI 1.55 to 10.77) is interesting.
Conclusions Acupuncture did not demonstrate specific efficacy over placebo and both groups did as well as normally expected with this condition.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1007/s00415-008-0790-1
ISSNs: 0340-5354 (print)
Related URLs:
Keywords: acupuncture, stroke, rehabilitation, randomised controlled trial, placebo
Subjects: R Medicine > RZ Other systems of medicine
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions : University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences
ePrint ID: 61817
Accepted Date and Publication Date:
June 2008Published
Date Deposited: 16 Sep 2008
Last Modified: 31 Mar 2016 12:45
URI: http://eprints.soton.ac.uk/id/eprint/61817

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