Issues with using baseline in last observation carried forward analysis

Julious, Steven A. and Mullee, Mark A. (2008) Issues with using baseline in last observation carried forward analysis. Pharmaceutical Statistics, 7, (2), 142-146. (doi:10.1002/pst.311).


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The topic of this paper was prompted by a study for which one of us was the statistician. It was submitted to Annals of Internal Medicine. The paper had positive reviewer comment; however, the statistical reviewer stated that for the analysis to be acceptable for publication, the missing data had to be accounted for in the analysis through the use of baseline in a last observation carried forward imputation. We discuss the issues associated with this form of imputation and recommend that it should not be undertaken as a primary analysis.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/pst.311
ISSNs: 1539-1604 (print)
Related URLs:
Keywords: missing data, england, clinical-trials, paper, imputation, time, baselines, observation,analysis, locf
Subjects: R Medicine > RM Therapeutics. Pharmacology
H Social Sciences > HA Statistics
Divisions : University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences
ePrint ID: 61843
Accepted Date and Publication Date:
April 2008Published
Date Deposited: 16 Sep 2008
Last Modified: 31 Mar 2016 12:45

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