Hering-Breuer reflex, lung volume and position in prematurely born infants


Landolfo, Francesca, Saiki, Tolulope, Peacock, Janet, Hannam, Simon, Rafferty, Gerrard F. and Greenough, Anne (2008) Hering-Breuer reflex, lung volume and position in prematurely born infants. Pediatric Pulmonology, 43, (8), 767-771. (doi:10.1002/ppul.20855). (PMID:18618620).

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Description/Abstract

OBJECTIVES: To investigate the effect of position on the strength of the Hering-Breuer reflex in prematurely born infants and determine whether any differences seen were related to differences in lung or tidal volume between positions. WORKING HYPOTHESIS: Position related differences in the strength of the Hering-Breuer reflex relate to differences in lung or tidal volume.
STUDY DESIGN: Prospective observational study. PATIENT/SUBJECT SELECTION: Eighteen infants, median gestational age 30 (range 25-32) weeks were studied. METHODOLOGY: Infants were examined in the supine and prone position, each position was maintained for 2 hr. At the end of each 2-hr period, the strength of the Hering-Breuer reflex was assessed by determining the prolongation of expiration following an end inspiratory occlusion. In addition, tidal volume and functional residual capacity (FRC) were assessed in each position.
RESULTS: The strength of the Hering-Breuer reflex was greater (P = 0.01) and the mean FRC was higher (P < 0.0001) in the prone compared to the supine position. The position related differences in the strength of the reflex correlated significantly with position related differences in FRC (P = 0.05). CONCLUSIONS: The Hering-Breuer reflex is stronger in the prone compared to the supine position. Our results suggest this is explained by position related differences in lung volume.

Item Type: Article
ISSNs: 8755-6863 (print)
1099-0496 (electronic)
Keywords: asthma, lung, design, infant, research support, gestational age, london, biology, functional residual capacity, research, strength, hypothesis
Subjects: R Medicine > RC Internal medicine
R Medicine > RJ Pediatrics
Divisions: University Structure - Pre August 2011 > School of Medicine
ePrint ID: 61899
Date Deposited: 16 Sep 2008
Last Modified: 27 Mar 2014 18:43
URI: http://eprints.soton.ac.uk/id/eprint/61899

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