Quantifying the advantages and disadvantages of pre-placement genetic screening
Palmer, K.T., Poole, J., Rawbone, R.G. and Coggon, D. (2004) Quantifying the advantages and disadvantages of pre-placement genetic screening. Occupational and Environmental Medicine, 61, (5), 448-453. (doi:10.1136/oem.2002.005611).
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BACKGROUND: Tests of genotype may enable workers at unusual risk of future ill-health to be identified. Using them to select for employment, however, entails gains and losses to employers and employees. Ensuring a fair balance between the rights and obligations of each group requires a value judgement, but the advantages and disadvantages to interested parties must first be quantified in a meaningful way.
METHOD AND RESULTS: The purposes of pre-employment screening are reviewed, and several simple measures relevant to the separate interests of employers and job applicants proposed-number screened to prevent a single adverse outcome; number excluded to prevent a case; expected incidence of the adverse outcome in those excluded; and preventable fraction. The derivation of these measures is illustrated, and the factors that influence them (the prevalence of the prognostic trait, the relative risk that it carries for an adverse outcome, and the overall incidence of disease) are related algebraically and graphically, to aid judgement on the utility of screening under different circumstances.
CONCLUSIONS: In sensitive areas such as genetic testing the onus should be on the employer to justify plans for pre-placement screening. Several quantitative measures can be used to inform the ethical and economic debate about screening and to evaluate alternative strategies for prevention.
|Keywords:||prevalence, genotype, personnel selection, economics, epidemiology, genetic predisposition to disease, cost-benefit analysis, occupational health services, medical, humans, disease, risk, incidence, environmental, ethics, employment, genetic screening|
Q Science > QH Natural history > QH426 Genetics
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences
|Date Deposited:||09 Sep 2008|
|Last Modified:||01 Jun 2011 00:44|
|Contributors:||Palmer, K.T. (Author)
Poole, J. (Author)
Rawbone, R.G. (Author)
Coggon, D. (Author)
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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